Preoperative Treatment of Locally Advanced Rectal Cancer

In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 389; no. 4; pp. 322 - 334
Main Authors: Schrag, Deborah, Shi, Qian, Weiser, Martin R., Gollub, Marc J., Saltz, Leonard B., Musher, Benjamin L., Goldberg, Joel, Al Baghdadi, Tareq, Goodman, Karyn A., McWilliams, Robert R., Farma, Jeffrey M., George, Thomas J., Kennecke, Hagen F., Shergill, Ardaman, Montemurro, Michael, Nelson, Garth D., Colgrove, Brian, Gordon, Vallerie, Venook, Alan P., O’Reilly, Eileen M., Meyerhardt, Jeffrey A., Dueck, Amylou C., Basch, Ethan, Chang, George J., Mamon, Harvey J.
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 27.07.2023
Subjects:
5-Fluorouracil
Adult
Anal Canal - surgery
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer
Cancer therapies
Chemoradiotherapy
Chemoradiotherapy - adverse effects
Chemoradiotherapy - methods
Chemotherapy
Chemotherapy, Adjuvant
Colorectal cancer
Death
Disease-Free Survival
Fluorouracil - administration & dosage
Fluorouracil - adverse effects
Gastroenterology
Gastrointestinal Tract Cancer
Hematology
Humans
Leucovorin - administration & dosage
Leucovorin - adverse effects
Neoadjuvant Therapy
Neoplasm Recurrence, Local - drug therapy
Neoplasm Staging
Oncology
Organ Sparing Treatments
Organoplatinum Compounds
Oxaliplatin
Oxaliplatin - administration & dosage
Oxaliplatin - adverse effects
Pathology
Patients
Pelvis
Preoperative Care
Preoperative Period
Radiation therapy
Rectal Neoplasms - mortality
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Rectum
Review boards
Sphincter
Statistical analysis
Surgeons
Surgery
Survival
Treatments in Oncology
Tumors
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa2303269