C5 nephritic factors drive the biological phenotype of C3 glomerulopathies

C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement. The potential role of the activation of the C5 convertase has not been studied extensively. Here we analy...

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Vydáno v:	Kidney international Ročník 92; číslo 5; s. 1232
Hlavní autoři:	Marinozzi, Maria-Chiara, Chauvet, Sophie, Le Quintrec, Moglie, Mignotet, Morgane, Petitprez, Florent, Legendre, Christophe, Cailliez, Mathilde, Deschenes, Georges, Fischbach, Michel, Karras, Alexandre, Nobili, Francois, Pietrement, Christine, Dragon-Durey, Marie-Agnes, Fakhouri, Fadi, Roumenina, Lubka T, Fremeaux-Bacchi, Veronique
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.11.2017
Témata:	Adolescent Adult Child Complement C3 Convertase, Alternative Pathway - immunology Complement C3 Nephritic Factor - analysis Complement C3 Nephritic Factor - genetics Complement C3 Nephritic Factor - immunology Complement C3-C5 Convertases - immunology Complement C3-C5 Convertases - metabolism Complement Membrane Attack Complex - analysis Complement Pathway, Alternative - immunology Female Follow-Up Studies Glomerulonephritis, Membranoproliferative - blood Glomerulonephritis, Membranoproliferative - genetics Glomerulonephritis, Membranoproliferative - immunology Glomerulonephritis, Membranoproliferative - mortality Humans Kaplan-Meier Estimate Male Middle Aged Phenotype Properdin - metabolism Serologic Tests Young Adult complement nephritic factor membranoproliferative glomerulonephritis
ISSN:	1523-1755, 1523-1755
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