Transcriptional census of epithelial-mesenchymal plasticity in cancer

Epithelial-mesenchymal plasticity is a prevalent source of intratumoral heterogeneity, driven by diverse molecular programs. Epithelial-mesenchymal plasticity (EMP) contributes to tumor progression, promoting therapy resistance and immune cell evasion. Definitive molecular features of this plasticit...

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Bibliographic Details
Published in:Science advances Vol. 8; no. 1; p. eabi7640
Main Authors: Cook, David P., Vanderhyden, Barbara C.
Format: Journal Article
Language:English
Published: United States American Association for the Advancement of Science 07.01.2022
Subjects:
Biomedicine and Life Sciences
Cancer
SciAdv r-articles
Systems Biology
ISSN:2375-2548, 2375-2548
Online Access:Get full text
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Summary:Epithelial-mesenchymal plasticity is a prevalent source of intratumoral heterogeneity, driven by diverse molecular programs. Epithelial-mesenchymal plasticity (EMP) contributes to tumor progression, promoting therapy resistance and immune cell evasion. Definitive molecular features of this plasticity have largely remained elusive due to the limited scale of most studies. Leveraging single-cell RNA sequencing data from 266 tumors spanning eight different cancer types, we identify expression patterns associated with intratumoral EMP. Integrative analysis of these programs confirmed a high degree of diversity among tumors. These diverse programs are associated with combinations of various common regulatory mechanisms initiated from cues within the tumor microenvironment. We show that inferring regulatory features can inform effective therapeutics to restrict EMP.
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ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.abi7640