Transcriptional census of epithelial-mesenchymal plasticity in cancer

Epithelial-mesenchymal plasticity is a prevalent source of intratumoral heterogeneity, driven by diverse molecular programs. Epithelial-mesenchymal plasticity (EMP) contributes to tumor progression, promoting therapy resistance and immune cell evasion. Definitive molecular features of this plasticit...

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Vydáno v:Science advances Ročník 8; číslo 1; s. eabi7640
Hlavní autoři: Cook, David P., Vanderhyden, Barbara C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Association for the Advancement of Science 07.01.2022
Témata:
Biomedicine and Life Sciences
Cancer
SciAdv r-articles
Systems Biology
ISSN:2375-2548, 2375-2548
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Shrnutí:Epithelial-mesenchymal plasticity is a prevalent source of intratumoral heterogeneity, driven by diverse molecular programs. Epithelial-mesenchymal plasticity (EMP) contributes to tumor progression, promoting therapy resistance and immune cell evasion. Definitive molecular features of this plasticity have largely remained elusive due to the limited scale of most studies. Leveraging single-cell RNA sequencing data from 266 tumors spanning eight different cancer types, we identify expression patterns associated with intratumoral EMP. Integrative analysis of these programs confirmed a high degree of diversity among tumors. These diverse programs are associated with combinations of various common regulatory mechanisms initiated from cues within the tumor microenvironment. We show that inferring regulatory features can inform effective therapeutics to restrict EMP.
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ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.abi7640