Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension

In this phase 1 study involving persons with hypertension, zilebesiran (an RNA interference therapeutic agent) was associated with decreases in angiotensin levels and systolic and diastolic blood pressure.

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Podrobná bibliografie
Vydáno v:The New England journal of medicine Ročník 389; číslo 3; s. 228 - 238
Hlavní autoři: Desai, Akshay S., Webb, David J., Taubel, Jorg, Casey, Sarah, Cheng, Yansong, Robbie, Gabriel J., Foster, Don, Huang, Stephen A., Rhyee, Sean, Sweetser, Marianne T., Bakris, George L.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Massachusetts Medical Society 20.07.2023
Témata:
Angiotensin
Angiotensinogen
Angiotensinogen - blood
Angiotensinogen - metabolism
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
Antihypertensive Agents - pharmacokinetics
Antihypertensive Agents - therapeutic use
Antihypertensives
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory
Cardiology
Diet
Double-Blind Method
Enzymes
Genetics
Genetics General
Humans
Hyperkalemia
Hypertension
Hypertension - blood
Hypertension - drug therapy
Hypertension - etiology
Hypertension - metabolism
Hypotension
Hypothesis testing
Injections, Subcutaneous
Irbesartan - administration & dosage
Irbesartan - adverse effects
Irbesartan - pharmacokinetics
Irbesartan - therapeutic use
Nutrient deficiency
Pharmacists
Pharmacodynamics
Pharmacokinetics
Renal function
Research ethics
RNA Interference
RNA Therapeutics
RNA-mediated interference
Salt
Tetrazoles
United Kingdom > UK
ISSN:0028-4793, 1533-4406, 1533-4406
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Popis
Shrnutí:In this phase 1 study involving persons with hypertension, zilebesiran (an RNA interference therapeutic agent) was associated with decreases in angiotensin levels and systolic and diastolic blood pressure.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa2208391