Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury

Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed nations. Bearing in mind the paucity of effective treatment for DN and progressive CKD, novel targets for treatment are sorely needed. We previously reported that increased activity of tonicity-responsive enhancer-bin...

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Veröffentlicht in:	Journal of the American Society of Nephrology Jg. 29; H. 2; S. 492
Hauptverfasser:	Choi, Soo Youn, Lim, Sun Woo, Salimi, Shabnam, Yoo, Eun Jin, Lee-Kwon, Whaseon, Lee, Hwan Hee, Lee, Jun Ho, Mitchell, Braxton D, Sanada, Satoru, Parsa, Afshin, Kwon, Hyug Moo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2018
Schlagworte:	Animals Blood Pressure - genetics Cell Movement Diabetes Mellitus - chemically induced Diabetic Nephropathies - etiology Diabetic Nephropathies - genetics Diabetic Nephropathies - pathology Gene Expression Glomerular Filtration Rate - genetics Haploinsufficiency Humans Hyperglycemia - complications Inflammation - etiology Inflammation - genetics Inflammation - pathology Macrophage Activation - genetics Macrophages - pathology Macrophages - physiology Mice Nitric Oxide Synthase Type III - genetics Polymorphism, Single Nucleotide Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - pathology Streptozocin Transcription Factors - genetics genetic variants blood pressure Diabetic nephropathy chronic kidney disease macrophages
ISSN:	1533-3450, 1533-3450
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