Identification of senescent cell surface targetable protein DPP4

Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human di...

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Bibliographic Details
Published in:	Genes & development Vol. 31; no. 15; p. 1529
Main Authors:	Kim, Kyoung Mi, Noh, Ji Heon, Bodogai, Monica, Martindale, Jennifer L, Yang, Xiaoling, Indig, Fred E, Basu, Sandip K, Ohnuma, Kei, Morimoto, Chikao, Johnson, Peter F, Biragyn, Arya, Abdelmohsen, Kotb, Gorospe, Myriam
Format:	Journal Article
Language:	English
Published:	United States 01.08.2017
Subjects:	Adult Aged Aged, 80 and over Antibody-Dependent Cell Cytotoxicity Cells, Cultured Cellular Senescence - physiology Cyclin-Dependent Kinase Inhibitor p16 - genetics Dipeptidyl Peptidase 4 - metabolism Diploidy Fibroblasts - metabolism Flow Cytometry Humans Killer Cells, Natural - metabolism Lymphocyte Subsets - enzymology Mass Spectrometry Membrane Proteins - metabolism RNA, Messenger - metabolism RNA, Ribosomal - metabolism human diploid fibroblasts CD26 cell senescence
ISSN:	1549-5477, 1549-5477
Online Access:	Get more information
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