Pharmacokinetics and Safety of Marqibo (Vincristine Sulfate Liposomes Injection) in Cancer Patients With Impaired Liver Function

Marqibo (vincristine sulfate liposome injection, VSLI) is a novel liposomal formulation of vincristine sulfate (VCR) being developed for the systemic treatment of cancer. This study evaluated the pharmacokinetics (PK) of Marqibo in subjects with melanoma and impaired hepatic function. Calculated PK...

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Bibliographic Details
Published in:	Journal of clinical pharmacology Vol. 51; no. 8; pp. 1205 - 1212
Main Authors:	Bedikian, Agop Y., Silverman, Jeffrey A., Papadopoulos, Nicholas E., Kim, Kevin B., Hagey, Anne E., Vardeleon, Anna, Hwu, Wen-Jen, Homsi, Jade, Davies, Michael, Hwu, Patrick
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.08.2011 SAGE Publications Wiley Subscription Services, Inc
Subjects:	Aged Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - pharmacokinetics Ascites - physiopathology Clinical pharmacology clinical research Female Half-Life Hepatic Insufficiency - etiology Humans Liposomes Liver cirrhosis Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - physiopathology Liver Neoplasms - secondary Male Melanoma - blood Melanoma - drug therapy Melanoma - metabolism Melanoma - secondary Metabolic Clearance Rate Middle Aged Neoplasm Staging oncology Pharmaceutical Vehicles - therapeutic use pharmacokinetics and drug metabolism pharmacology Skin Neoplasms - blood Skin Neoplasms - complications Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Survival Analysis Tubulin Modulators - administration & dosage Tubulin Modulators - adverse effects Tubulin Modulators - blood Tubulin Modulators - pharmacokinetics Uveal Neoplasms - blood Uveal Neoplasms - complications Uveal Neoplasms - drug therapy Uveal Neoplasms - metabolism Vincristine - administration & dosage Vincristine - adverse effects Vincristine - blood Vincristine - pharmacokinetics
ISSN:	0091-2700, 1552-4604, 1552-4604
Online Access:	Get full text
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