Stem-Loop Structures within mRNA Coding Sequences Activate Translation Initiation and Mediate Control by Small Regulatory RNAs

Initiation is the rate-limiting step of translation, and in bacteria, mRNA secondary structure has been extensively reported as limiting the efficiency of translation by occluding the ribosome-binding site. In striking contrast with this inhibitory effect, we report here that stem-loop structures lo...

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Veröffentlicht in:	Molecular cell Jg. 68; H. 1; S. 158
Hauptverfasser:	Jagodnik, Jonathan, Chiaruttini, Claude, Guillier, Maude
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.10.2017
Schlagworte:	Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Base Pairing Base Sequence Carrier Proteins - genetics Carrier Proteins - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Inverted Repeat Sequences Iron - metabolism Nucleic Acid Conformation Open Reading Frames Peptide Chain Initiation, Translational Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Ribosomes - genetics Ribosomes - metabolism RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Untranslated - genetics RNA, Small Untranslated - metabolism BAM complex enterobactin Hfq regulatory mechanism non-coding RNA regulatory RNA toeprint translation-activating structure starting block siderophore
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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