Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during early carcinogenesis of lung adenocarcinoma has not been systematically studied. We perform reduced representation bisulfite sequencing of invasive lung adenocarcinoma and its precursors, atypical adenomatous hyper...

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Published in:	Nature communications Vol. 12; no. 1; pp. 687 - 13
Main Authors:	Hu, Xin, Estecio, Marcos R., Chen, Runzhe, Reuben, Alexandre, Wang, Linghua, Fujimoto, Junya, Carrot-Zhang, Jian, McGranahan, Nicholas, Ying, Lisha, Fukuoka, Junya, Chow, Chi-Wan, Pham, Hoa H. N., Godoy, Myrna C. B., Carter, Brett W., Behrens, Carmen, Zhang, Jianhua, Antonoff, Mara B., Sepesi, Boris, Lu, Yue, Pass, Harvey I., Kadara, Humam, Scheet, Paul, Vaporciyan, Ara A., Heymach, John V., Wistuba, Ignacio I., Lee, J. Jack, Futreal, P. Andrew, Su, Dan, Issa, Jean-Pierre J., Zhang, Jianjun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.01.2021 Nature Publishing Group Nature Portfolio
Subjects:	45 45/23 631/208/177 631/67/1612/1350 631/67/2329 631/67/69 Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - mortality Adenocarcinoma of Lung - pathology Adult Aged Aged, 80 and over Bisulfite Carcinogenesis Carcinogenesis - genetics Carcinogens CD8 antigen Chromosomal Instability Convolution Copy number Deoxyribonucleic acid Disease Progression DNA DNA Copy Number Variations DNA methylation DNA Methylation - genetics Epigenome - genetics Evolution Evolution & development Female Genetic Heterogeneity Genomic instability Heterogeneity Humanities and Social Sciences Humans Hyperplasia Hyperplasia - genetics Hyperplasia - pathology Immunoregulation Immunosuppression Lesions Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Lungs Lymphocytes Lymphocytes T Male Metastases Microenvironments Middle Aged multidisciplinary Mutagenesis Mutation Mutation Rate Phylogeny Precancerous Conditions - genetics Precancerous Conditions - pathology Science Science (multidisciplinary) Survival Analysis Tumor Microenvironment - genetics Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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