The role of MiRNA in polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RN...

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Vydané v:	Gene Ročník 706; s. 91 - 96
Hlavní autori:	Chen, Baiqi, Xu, Ping, Wang, Jing, Zhang, Chunping
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 20.07.2019
Predmet:	adipose tissue anovulation blood serum diabetes Follicular fluid gene expression regulation granulosa cells hyperandrogenism insulin resistance leukocytes microRNA MiRNA neoplasms non-coding RNA obesity PCOS polycystic ovary syndrome women LHCGR miRNAs IRS1 T2D MiRNA IR Follicular fluid IGM PCOS UTR CCs AT NGT GLUT4
ISSN:	0378-1119, 1879-0038, 1879-0038
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Abstract	Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RNAs which are involved in the regulation of gene expression at the post-transcriptional level. Altered miRNAs levels have been showed to be associated with a variety of diseases including diabetes, endometriosis and cancer. In recent years, more and more evidence suggests abnormal expression of miRNAs are detected in granulosa cells, theca cells, adipose tissue, follicular fluid, serum and peripheral blood leukocytes of women with PCOS and display vital role in the occurrence and development of PCOS. This will shed light on new strategies for the diagnosis and treatment of this syndrome. In this paper, we will review the recent research on miRNAs with respect to PCOS. •MiRNAs are involved in broad physiological processes.•Dysregulated miRNAs could be detected within cells and extracelluar fluids of Polycystic Ovary Syndrome patients and were involved in the pathogenesis of Polycystic Ovary Syndrome.
AbstractList	Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RNAs which are involved in the regulation of gene expression at the post-transcriptional level. Altered miRNAs levels have been showed to be associated with a variety of diseases including diabetes, endometriosis and cancer. In recent years, more and more evidence suggests abnormal expression of miRNAs are detected in granulosa cells, theca cells, adipose tissue, follicular fluid, serum and peripheral blood leukocytes of women with PCOS and display vital role in the occurrence and development of PCOS. This will shed light on new strategies for the diagnosis and treatment of this syndrome. In this paper, we will review the recent research on miRNAs with respect to PCOS. •MiRNAs are involved in broad physiological processes.•Dysregulated miRNAs could be detected within cells and extracelluar fluids of Polycystic Ovary Syndrome patients and were involved in the pathogenesis of Polycystic Ovary Syndrome. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RNAs which are involved in the regulation of gene expression at the post-transcriptional level. Altered miRNAs levels have been showed to be associated with a variety of diseases including diabetes, endometriosis and cancer. In recent years, more and more evidence suggests abnormal expression of miRNAs are detected in granulosa cells, theca cells, adipose tissue, follicular fluid, serum and peripheral blood leukocytes of women with PCOS and display vital role in the occurrence and development of PCOS. This will shed light on new strategies for the diagnosis and treatment of this syndrome. In this paper, we will review the recent research on miRNAs with respect to PCOS. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RNAs which are involved in the regulation of gene expression at the post-transcriptional level. Altered miRNAs levels have been showed to be associated with a variety of diseases including diabetes, endometriosis and cancer. In recent years, more and more evidence suggests abnormal expression of miRNAs are detected in granulosa cells, theca cells, adipose tissue, follicular fluid, serum and peripheral blood leukocytes of women with PCOS and display vital role in the occurrence and development of PCOS. This will shed light on new strategies for the diagnosis and treatment of this syndrome. In this paper, we will review the recent research on miRNAs with respect to PCOS.Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RNAs which are involved in the regulation of gene expression at the post-transcriptional level. Altered miRNAs levels have been showed to be associated with a variety of diseases including diabetes, endometriosis and cancer. In recent years, more and more evidence suggests abnormal expression of miRNAs are detected in granulosa cells, theca cells, adipose tissue, follicular fluid, serum and peripheral blood leukocytes of women with PCOS and display vital role in the occurrence and development of PCOS. This will shed light on new strategies for the diagnosis and treatment of this syndrome. In this paper, we will review the recent research on miRNAs with respect to PCOS.
Author	Zhang, Chunping Xu, Ping Wang, Jing Chen, Baiqi
Author_xml	– sequence: 1 givenname: Baiqi surname: Chen fullname: Chen, Baiqi organization: School of Public Health, Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China – sequence: 2 givenname: Ping surname: Xu fullname: Xu, Ping organization: Second Clinical College, Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China – sequence: 3 givenname: Jing surname: Wang fullname: Wang, Jing organization: Department of Microbiology, Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China – sequence: 4 givenname: Chunping orcidid: 0000-0002-0159-4547 surname: Zhang fullname: Zhang, Chunping email: zhangcp81@163.com organization: Department of Cell Biology, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31054362$$D View this record in MEDLINE/PubMed
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Snippet	Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic...
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SubjectTerms	adipose tissue anovulation blood serum diabetes Follicular fluid gene expression regulation granulosa cells hyperandrogenism insulin resistance leukocytes microRNA MiRNA neoplasms non-coding RNA obesity PCOS polycystic ovary syndrome women
Title	The role of MiRNA in polycystic ovary syndrome (PCOS)
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