The role of MiRNA in polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RN...

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Vydáno v:Gene Ročník 706; s. 91 - 96
Hlavní autoři: Chen, Baiqi, Xu, Ping, Wang, Jing, Zhang, Chunping
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 20.07.2019
Témata:
adipose tissue
anovulation
blood serum
diabetes
Follicular fluid
gene expression regulation
granulosa cells
hyperandrogenism
insulin resistance
leukocytes
microRNA
MiRNA
neoplasms
non-coding RNA
obesity
PCOS
polycystic ovary syndrome
women
LHCGR
miRNAs
IRS1
T2D
MiRNA
IR
Follicular fluid
IGM
PCOS
UTR
CCs
AT
NGT
GLUT4
ISSN:0378-1119, 1879-0038, 1879-0038
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Popis
Shrnutí:Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic ovaries and being frequently accompanied by insulin resistance (IR) and obesity. MicroRNAs (miRNAs) are short non-coding RNAs which are involved in the regulation of gene expression at the post-transcriptional level. Altered miRNAs levels have been showed to be associated with a variety of diseases including diabetes, endometriosis and cancer. In recent years, more and more evidence suggests abnormal expression of miRNAs are detected in granulosa cells, theca cells, adipose tissue, follicular fluid, serum and peripheral blood leukocytes of women with PCOS and display vital role in the occurrence and development of PCOS. This will shed light on new strategies for the diagnosis and treatment of this syndrome. In this paper, we will review the recent research on miRNAs with respect to PCOS. •MiRNAs are involved in broad physiological processes.•Dysregulated miRNAs could be detected within cells and extracelluar fluids of Polycystic Ovary Syndrome patients and were involved in the pathogenesis of Polycystic Ovary Syndrome.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0378-1119
1879-0038
1879-0038
DOI:10.1016/j.gene.2019.04.082