Altered mitochondrial DNA methylation and mitochondrial DNA copy number in an APP/PS1 transgenic mouse model of Alzheimer disease

Alzheimer’s disease (AD) is a chronic neurodegenerative disease and mitochondrial impairment is a key feature of AD. The mitochondrial DNA (mtDNA) epigenetic mechanism is a relatively new field compared to nuclear DNA. The relationship between mtDNA epigenetic mechanism and AD hasn’t been establishe...

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Veröffentlicht in:	Biochemical and biophysical research communications Jg. 520; H. 1; S. 41 - 46
Hauptverfasser:	Xu, YingYing, Xu, LinLin, Han, Min, Liu, XiangTian, Li, Fan, Zhou, XiaoYan, Wang, Yun, Bi, JianZhong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.11.2019
Schlagworte:	12S rRNA gene Alzheimer disease Alzheimer’s disease amyloid APP/PS1 transgenic mice bisulfites D-loop DNA methylation epigenetics gene expression high-throughput nucleotide sequencing mice mitochondria mitochondrial DNA Mitochondrial DNA copy number Mitochondrial DNA methylation mitochondrial genes neurodegenerative diseases nuclear genome quantitative polymerase chain reaction Mitochondrial DNA copy number APP/PS1 transgenic mice D-loop Alzheimer’s disease 12S rRNA gene Mitochondrial DNA methylation
ISSN:	0006-291X, 1090-2104, 1090-2104
Online-Zugang:	Volltext
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