A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

Summary Three lipophilic quinazoline-based aminomethyl pyridine compounds, which differ only in the position of the nitrogen in their pyridine ring, are described. CB300179 (2-pyridine), CB300189 (4-pyridine) and CB30865 (3-pyridine) all inhibited isolated mammalian TS with IC 50 values of 508, 250...

Full description

Saved in:

Bibliographic Details
Published in:	British journal of cancer Vol. 79; no. 11; pp. 1692 - 1701
Main Authors:	Skelton, L A, Ormerod, M G, Titley, J, Kimbell, R, Brunton, L A, Jackman, A L
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.04.1999 Nature Publishing Group
Subjects:	Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Cycle - drug effects Cell Division - drug effects Cell Survival - drug effects Chemical Precipitation Colony-Forming Units Assay Cytoprotection DNA, Neoplasm - biosynthesis Drug Resistance Epidemiology Folic Acid - pharmacology General aspects Humans Leukemia L1210 - drug therapy Leukemia L1210 - pathology Lipid Metabolism Medical sciences Mice Molecular Medicine Oncology Pharmacology. Drug treatments Quinazolines - therapeutic use Regular regular-article Solubility Tumor Cells, Cultured folate-independent cross-resistance cell cycle CB30865 ZM198583 TS Antineoplastic agent Quinazoline derivatives Cytotoxicity L1210-Leukemia Folic acid Folate Pyridine derivatives Lipophilic compound Cell cycle Established cell line Cross resistance Mechanism of action Lymphoblastoid cell Negative therapeutic reaction Human Enzyme Transferases Rodentia Malignant hemopathy Malignant tumor Thymidylate synthase In vitro Vertebrata Mammalia Methyltransferases Mouse Analog Animal
ISSN:	0007-0920, 1532-1827
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!