Six-Minute Walk, Maximal Exercise Tests: Reproducibility in Fibrotic Interstitial Pneumonia

Resting pulmonary function and exercise variables are widely used to stage and monitor idiopathic interstitial pneumonia (IIP). However, the variability of exercise data (maximal exercise and the 6-minute walk test) has not been evaluated definitively. We have prospectively quantified the reproducib...

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Vydáno v:American journal of respiratory and critical care medicine Ročník 171; číslo 10; s. 1150 - 1157
Hlavní autoři: Eaton, Tam, Young, Pam, Milne, David, Wells, Athol U
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York, NY Am Thoracic Soc 15.05.2005
American Lung Association
American Thoracic Society
Témata:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Blood coagulation
Exercise Test - methods
Female
Follow-Up Studies
Human bacterial diseases
Humans
Infectious diseases
Intensive care medicine
Investigative techniques, diagnostic techniques (general aspects)
Lung Volume Measurements
Male
Medical sciences
Oxygen Consumption
Physical Endurance
Pulmonary Diffusing Capacity
Pulmonary Fibrosis - diagnosis
Pulmonary Fibrosis - physiopathology
Reproducibility of Results
Survival Analysis
Walking
Physical exercise
Lung disease
Intensive care
exercise tests
Respiratory disease
Reproducibility
interstitial lung disease
Variability
Interstitial pneumonitis
Interstitial
Resuscitation
ISSN:1073-449X, 1535-4970
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Shrnutí:Resting pulmonary function and exercise variables are widely used to stage and monitor idiopathic interstitial pneumonia (IIP). However, the variability of exercise data (maximal exercise and the 6-minute walk test) has not been evaluated definitively. We have prospectively quantified the reproducibility of resting and exercise functional data in fibrotic IIP (idiopathic pulmonary fibrosis, fibrotic nonspecific interstitial pneumonia) and have evaluated interrelationships between variables. Thirty consecutive patients with fibrotic IIP underwent serial resting pulmonary function tests, 6-minute walk (n = 29), and maximal exercise (n = 24) at an interval of 1 week, with all testing performed in accordance with American Thoracic Society standards. Within-subject reproducibility was excellent for 6-minute walk distance (SD/mean = 4.2%) and clinically acceptable for resting pulmonary function indices and VO(2)max on maximal exercise testing. However, the amplitude of oxygen desaturation at the end of exercise was poorly reproducible in both 6-minute walk and maximal exercise testing (SD/mean > 25%). There was a highly significant relationship between VO2max on maximal exercise testing and 6-minute walk distance (r(s) = 0.78, p < 0.0001). In fibrotic IIP, the excellent reproducibility of the 6-minute walk distance is a major advantage in routine staging and monitoring, whereas maximal exercise variables are poorly reproducible.
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ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.200405-578OC