Finite and infinite dosing: Difficulties in measurements, evaluations and predictions

Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. Howev...

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Bibliographic Details
Published in:Advanced drug delivery reviews Vol. 65; no. 2; pp. 278 - 294
Main Authors: Selzer, Dominik, Abdel-Mottaleb, Mona M.A., Hahn, Tsambika, Schaefer, Ulrich F., Neumann, Dirk
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.02.2013
Subjects:
Animals
Concentration-depth profile
Dose-Response Relationship, Drug
Drug Delivery Systems
Humans
In vitro
In vivo
Models, Theoretical
Penetration
Permeability
Permeation
Skin - metabolism
Skin Absorption
Tape stripping
Xenobiotics - administration & dosage
Xenobiotics - pharmacokinetics
Tape stripping
In vivo
Penetration
In vitro
Concentration-depth profile
Permeation
ISSN:0169-409X, 1872-8294, 1872-8294
Online Access:Get full text
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Summary:Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. However, the experiments described in literature and the subsequent evaluation procedures differ considerably. Here we will give an overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data. We will point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo. [Display omitted]
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2012.06.010