Finite and infinite dosing: Difficulties in measurements, evaluations and predictions

Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. Howev...

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Vydáno v:Advanced drug delivery reviews Ročník 65; číslo 2; s. 278 - 294
Hlavní autoři: Selzer, Dominik, Abdel-Mottaleb, Mona M.A., Hahn, Tsambika, Schaefer, Ulrich F., Neumann, Dirk
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.02.2013
Témata:
Animals
Concentration-depth profile
Dose-Response Relationship, Drug
Drug Delivery Systems
Humans
In vitro
In vivo
Models, Theoretical
Penetration
Permeability
Permeation
Skin - metabolism
Skin Absorption
Tape stripping
Xenobiotics - administration & dosage
Xenobiotics - pharmacokinetics
Tape stripping
In vivo
Penetration
In vitro
Concentration-depth profile
Permeation
ISSN:0169-409X, 1872-8294, 1872-8294
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Abstract Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. However, the experiments described in literature and the subsequent evaluation procedures differ considerably. Here we will give an overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data. We will point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo. [Display omitted]
AbstractList Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. However, the experiments described in literature and the subsequent evaluation procedures differ considerably. Here we will give an overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data. We will point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo.Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. However, the experiments described in literature and the subsequent evaluation procedures differ considerably. Here we will give an overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data. We will point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo.
Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. However, the experiments described in literature and the subsequent evaluation procedures differ considerably. Here we will give an overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data. We will point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo.
Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been gaining in importance steadily. In vitro experiments allow for determining these data faster and more easily than in vivo experiments. However, the experiments described in literature and the subsequent evaluation procedures differ considerably. Here we will give an overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data. We will point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo. [Display omitted]
Author Abdel-Mottaleb, Mona M.A.
Hahn, Tsambika
Schaefer, Ulrich F.
Selzer, Dominik
Neumann, Dirk
Author_xml – sequence: 1
  givenname: Dominik
  surname: Selzer
  fullname: Selzer, Dominik
  organization: Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
– sequence: 2
  givenname: Mona M.A.
  surname: Abdel-Mottaleb
  fullname: Abdel-Mottaleb, Mona M.A.
  organization: Department of Pharmaceutics and Industrial Pharmacy, Ain Shams University, Cairo, Egypt
– sequence: 3
  givenname: Tsambika
  surname: Hahn
  fullname: Hahn, Tsambika
  organization: Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
– sequence: 4
  givenname: Ulrich F.
  surname: Schaefer
  fullname: Schaefer, Ulrich F.
  organization: Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
– sequence: 5
  givenname: Dirk
  surname: Neumann
  fullname: Neumann, Dirk
  email: d.neumann@scientific-consilience.com
  organization: Scientific Consilience, Saarland University, Saarbruecken, Germany
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22750806$$D View this record in MEDLINE/PubMed
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1872-8294
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Issue 2
Keywords Tape stripping
In vivo
Penetration
In vitro
Concentration-depth profile
Permeation
Language English
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PublicationDateYYYYMMDD 2013-02-01
PublicationDate_xml – month: 02
  year: 2013
  text: February 2013
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Advanced drug delivery reviews
PublicationTitleAlternate Adv Drug Deliv Rev
PublicationYear 2013
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
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SecondaryResourceType review_article
Snippet Due to the increased demand for reliable data regarding penetration into and permeation across human skin, assessment of the absorption of xenobiotics has been...
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SubjectTerms Animals
Concentration-depth profile
Dose-Response Relationship, Drug
Drug Delivery Systems
Humans
In vitro
In vivo
Models, Theoretical
Penetration
Permeability
Permeation
Skin - metabolism
Skin Absorption
Tape stripping
Xenobiotics - administration & dosage
Xenobiotics - pharmacokinetics
Title Finite and infinite dosing: Difficulties in measurements, evaluations and predictions
URI https://dx.doi.org/10.1016/j.addr.2012.06.010
https://www.ncbi.nlm.nih.gov/pubmed/22750806
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Volume 65
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