Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling

Nuclear factor erythroid 2-related factor 2 (NRF2) plays a vital role in the regulation of various antioxidant response element (ARE) genes, which control physiological processes such as oxidative stress, autophagy, proliferation and apoptosis to maintain cellular homeostasis. It is not understood i...

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Bibliographic Details
Published in:	Toxicology (Amsterdam) Vol. 519; p. 154284
Main Authors:	Sharma, Raju Prasad, Loonstra-Wolters, Liesanne, ter Braak, Bas, Niemeijer, Marije, White, Andrew, van de Water, Bob, Middleton, Alistair M., Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01.01.2026
Subjects:	Chemical exposure Computer Simulation Emergency Hep G2 Cells Hepatotoxicity Humans Models, Biological NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nonlinear mixed effect modeling NRF2 Oxidoreductases Acting on Sulfur Group Donors - genetics Oxidoreductases Acting on Sulfur Group Donors - metabolism Repeated exposure SRXN1 Repeated exposure Chemical exposure NRF2 SRXN1 Hepatotoxicity Nonlinear mixed effect modeling
ISSN:	0300-483X, 1879-3185, 1879-3185
Online Access:	Get full text
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