Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Immune cells function in diverse metabolic environments. Tissues with low glucose and high lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require immune responses to be more pro-tolerant, avoiding unwanted reactions against self-antigens or commensal bacteria. T...

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Veröffentlicht in:	Cell metabolism Jg. 25; H. 6; S. 1282
Hauptverfasser:	Angelin, Alessia, Gil-de-Gómez, Luis, Dahiya, Satinder, Jiao, Jing, Guo, Lili, Levine, Matthew H, Wang, Zhonglin, Quinn, 3rd, William J, Kopinski, Piotr K, Wang, Liqing, Akimova, Tatiana, Liu, Yujie, Bhatti, Tricia R, Han, Rongxiang, Laskin, Benjamin L, Baur, Joseph A, Blair, Ian A, Wallace, Douglas C, Hancock, Wayne W, Beier, Ulf H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.06.2017
Schlagworte:	Animals Cell Line Cellular Microenvironment - genetics Cellular Microenvironment - immunology Cellular Reprogramming - genetics Cellular Reprogramming - immunology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology Glucose - genetics Glucose - immunology Glycolysis - genetics Glycolysis - immunology Humans Lactic Acid - immunology Mice Mice, Inbred BALB C Mice, Knockout Oxidative Phosphorylation Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - immunology T-Lymphocytes, Regulatory - immunology immunometabolism T cell metabolism immune regulation
ISSN:	1932-7420, 1932-7420
Online-Zugang:	Weitere Angaben
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