Synthesis of silica-polymer core-shell nanoparticles by reversible addition-fragmentation chain transfer polymerization

Hybrid nanoparticles hold great promise for a range of applications such as drug-delivery vectors or colloidal crystal self-assemblies. The challenge of preparing highly monodisperse particles for these applications has recently been overcome by using living radical polymerization techniques. In par...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 49; no. 80; p. 9077
Main Authors: Moraes, John, Ohno, Kohji, Maschmeyer, Thomas, Perrier, Sébastien
Format: Journal Article
Language:English
Published: England 01.01.2013
Subjects:
Colloids - chemistry
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Free Radicals - chemistry
Nanoparticles - chemistry
Polymerization
Polymers - chemistry
Silicon Dioxide - chemistry
Surface Properties
ISSN:1364-548X, 1364-548X
Online Access:Get more information
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Summary:Hybrid nanoparticles hold great promise for a range of applications such as drug-delivery vectors or colloidal crystal self-assemblies. The challenge of preparing highly monodisperse particles for these applications has recently been overcome by using living radical polymerization techniques. In particular, the use of reversible addition-fragmentation chain transfer (RAFT), initiated from silica surfaces, yields well-defined particles from a range of precursor monomers resulting in nanoparticles of tailored sizes that are accessible via the rational selection of polymerization conditions. Furthermore, using RAFT allows post-polymerization modification to afford multifunctional, monodisperse, nanostructures under mild and non-stringent reaction conditions.
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ISSN:1364-548X
1364-548X
DOI:10.1039/c3cc45319g