Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis

Pulmonary fibrosis is characterized by progressive and irreversible scarring of alveoli, which causes reduction of surface epithelial area and eventually respiratory failure. The precise mechanism of alveolar scarring is poorly understood. In this study, we explored transcriptional signatures of act...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 514; no. 3; pp. 684 - 690
Main Authors:	Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Hashimoto, Shinichi, Nakajima, Takuya, Shiraishi, Kazushige, Kihara, Miho, Kiyonari, Hiroshi, Inagaki, Yutaka, Matsushima, Kouji
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 30.06.2019
Subjects:	epithelium extracellular matrix Fibroblasts fibrosis GANT61 gene expression regulation Gli pathway lungs metabolism mice oncogenes Pulmonary fibrosis Scar signal transduction transcription (genetics) transcription factors translation (genetics) Wound healing BLM Wound healing Gli Scar ECM α-SMA mKO1 Pulmonary fibrosis Col-GFP Fibroblasts Gli pathway GANT61 IPF
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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