Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding

Post-translational modification (PTM) of proteins regulates cellular proteostasis by expanding protein functional diversity. This naturally leads to increased proteome complexity as a result of PTM crosstalk. Here, we used the molecular chaperone protein, Heat shock protein-90 (Hsp90), which is subj...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 301; no. 9; p. 110519
Main Authors:	Heritz, Jennifer A., Meluni, Katherine A., Backe, Sarah J., Cayaban, Sara J., Wengert, Laura A., Kunz, Meik, Woodford, Mark R., Bourboulia, Dimitra, Mollapour, Mehdi
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2025 American Society for Biochemistry and Molecular Biology
Subjects:	Acetylation artificial intelligence chaperone cochaperone Deep Learning histone deacetylase Histone Deacetylases - genetics Histone Deacetylases - metabolism Hsp90 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - chemistry HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Phosphorylation Protein Binding Protein Processing, Post-Translational Repressor Proteins GIST cochaperone CML KO AI PTM histone deacetylase artificial intelligence Hsp90 acetylation deep learning Q R chaperone MIND-S Bio-GB GB phosphorylation WT HDAC
ISSN:	0021-9258, 1083-351X, 1083-351X
Online Access:	Get full text
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