Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

Advanced age is associated with a disproportionate prevalence of cardiovascular disease (CVD). Intrinsic alterations in the heart and the vasculature occurring over the life course render the cardiovascular system more vulnerable to various stressors in late life, ultimately favoring the development...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology Jg. 305; H. 4; S. H459
Hauptverfasser:	Marzetti, Emanuele, Csiszar, Anna, Dutta, Debapriya, Balagopal, Gauthami, Calvani, Riccardo, Leeuwenburgh, Christiaan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.08.2013
Schlagworte:	Age Factors Aging - metabolism Aging - pathology Animals Autophagy Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Cardiovascular System - metabolism Cardiovascular System - pathology Cardiovascular System - physiopathology Humans Mitochondria - metabolism Mitochondria - pathology Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondria, Muscle - metabolism Mitochondria, Muscle - pathology Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Neurons - metabolism Neurons - pathology Oxidative Stress Prognosis Risk Factors Translational Medical Research neurodegeneration mitophagy fusion and fission resveratrol oxidative stress
ISSN:	1522-1539, 1522-1539
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