Adaptive mutability of colorectal cancers in response to targeted therapies

The emergence of drug resistance limits the efficacy of targeted therapies in human tumors. The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers already contain drug-resistant mutant cells. Bacteria exposed to antibiotics transiently increase their mutation...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) Vol. 366; no. 6472; p. 1473
Main Authors:	Russo, Mariangela, Crisafulli, Giovanni, Sogari, Alberto, Reilly, Nicole M, Arena, Sabrina, Lamba, Simona, Bartolini, Alice, Amodio, Vito, Magrì, Alessandro, Novara, Luca, Sarotto, Ivana, Nagel, Zachary D, Piett, Cortt G, Amatu, Alessio, Sartore-Bianchi, Andrea, Siena, Salvatore, Bertotti, Andrea, Trusolino, Livio, Corigliano, Mattia, Gherardi, Marco, Lagomarsino, Marco Cosentino, Di Nicolantonio, Federica, Bardelli, Alberto
Format:	Journal Article
Language:	English
Published:	United States 20.12.2019
Subjects:	Adaptation, Biological - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA Mismatch Repair - genetics Down-Regulation Drug Resistance, Neoplasm - genetics ErbB Receptors - antagonists & inhibitors Humans Molecular Targeted Therapy Mutagenesis Proto-Oncogene Proteins B-raf - antagonists & inhibitors Selection, Genetic
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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