Sry and the hesitant beginnings of male development

In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discov...

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Bibliographic Details
Published in:Developmental biology Vol. 302; no. 1; pp. 13 - 24
Main Authors: Polanco, Juan Carlos, Koopman, Peter
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.02.2007
Subjects:
Amino Acid Sequence
Animals
Brain gender
Evolution
Female
Gene Expression Regulation, Developmental
Genes, sry
High Mobility Group Proteins - genetics
Humans
Male
Molecular mechanism
Molecular Sequence Data
Organ Specificity
Sex determination
Sex Determination Processes
Sex Differentiation - genetics
Sex-Determining Region Y Protein - chemistry
Sex-Determining Region Y Protein - metabolism
SOX9 Transcription Factor
Sry
Testis development
Transcription Factors - genetics
Testis development
Evolution
Brain gender
Sry
Sex determination
Molecular mechanism
ISSN:0012-1606, 1095-564X
Online Access:Get full text
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Summary:In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discovered, and the mechanisms by which it mediates its developmental functions are still elusive. What is clear is that instead of the robust gene one might expect as the pillar of male sexual development, Sry function hangs by a thin thread, a situation that has profound biological, medical and evolutionary implications.
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ISSN:0012-1606
1095-564X
DOI:10.1016/j.ydbio.2006.08.049