Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

Objective Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis (MS), but can these changes be identified in the patient early in the disease course? Methods To identify possible biomarkers linking...

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Bibliographic Details
Published in:	Annals of neurology Vol. 83; no. 4; pp. 739 - 755
Main Authors:	Magliozzi, Roberta, Howell, Owain W., Nicholas, Richard, Cruciani, Carolina, Castellaro, Marco, Romualdi, Chiara, Rossi, Stefania, Pitteri, Marco, Benedetti, Maria Donata, Gajofatto, Alberto, Pizzini, Francesca B., Montemezzi, Stefania, Rasia, Sarah, Capra, Ruggero, Bertoldo, Alessandra, Facchiano, Francesco, Monaco, Salvatore, Reynolds, Richard, Calabrese, Massimiliano
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.04.2018
Subjects:	Adult Aged Aged, 80 and over APRIL protein Autopsy Biomarkers BLyS protein Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cerebrospinal fluid Cohort Studies Cortex CXCL10 protein CXCL12 protein CXCL13 protein Cytokines Cytokines - cerebrospinal fluid Damage detection Demyelination Diagnosis Disease Progression Female Gelatinase A Gene expression Gray Matter - diagnostic imaging Gray Matter - pathology Humans Identification methods Image Processing, Computer-Assisted Inflammation Interleukin 1 Interleukin 10 Interleukin 2 Interleukin 22 Interleukin 6 Interleukin 8 Light levels Lymphocytes B Magnetic Resonance Imaging Male Meninges Meninges - diagnostic imaging Meninges - metabolism Middle Aged Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology NMR Nuclear magnetic resonance Patients ROC Curve Substantia grisea γ-Interferon
ISSN:	0364-5134, 1531-8249, 1531-8249
Online Access:	Get full text
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