Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability

Objective Leucine‐rich glioma‐inactivated 1 (LGI1) encephalitis is the second most common antibody‐mediated encephalopathy, but insight into the intrathecal B‐cell autoimmune response, including clonal relationships, isotype distribution, frequency, and pathogenic effects of single LGI1 antibodies,...

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Bibliographic Details
Published in:	Annals of neurology Vol. 87; no. 3; pp. 405 - 418
Main Authors:	Kornau, Hans‐Christian, Kreye, Jakob, Stumpf, Alexander, Fukata, Yuko, Parthier, Daniel, Sammons, Rosanna P., Imbrosci, Barbara, Kurpjuweit, Sarah, Kowski, Alexander B., Fukata, Masaki, Prüss, Harald, Schmitz, Dietmar
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.03.2020 Wiley Subscription Services, Inc
Subjects:	Antibodies Autoantibodies Brain Brain slice preparation Cerebrospinal fluid Encephalitis Encephalopathy Epitopes Excitability Glioma Glutamatergic transmission Hippocampus Immunoglobulin G Immunoglobulins Immunological memory Leucine LGI1 protein Lymphocytes B Memory cells Seizures Synaptic transmission
ISSN:	0364-5134, 1531-8249, 1531-8249
Online Access:	Get full text
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