Thrombin contributes to protective immunity in pneumonia‐derived sepsis via fibrin polymerization and platelet–neutrophil interactions

Essentials Immunity and coagulation are linked during sepsis but the role of thrombin is not fully elucidated. We investigated the effect of thrombin inhibition on murine Klebsiella pneumosepsis outcome. Thrombin is crucial for survival and limiting bacterial growth in pneumonia derived sepsis. Thro...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 15; no. 4; pp. 744 - 757
Main Authors:	Claushuis, T. A. M., Stoppelaar, S. F., Stroo, I., Roelofs, J. J. T. H., Ottenhoff, R., Poll, T., Veer, C.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01.04.2017
Subjects:	Animals Blood Coagulation Blood platelets Blood Platelets - cytology Cell Communication dabigatran Dabigatran - administration & dosage Extracellular Traps Female fibrin Fibrin - chemistry Fibrinogen - chemistry Flow Cytometry Humans Immune System Immunity, Innate infection Klebsiella Infections - immunology Klebsiella pneumoniae Lung - pathology Mice Mice, Inbred C57BL Microcirculation Neutrophils Neutrophils - cytology Pneumonia Pneumonia, Bacterial - immunology Polymerization Sepsis Sepsis - immunology Sepsis - microbiology thrombin Thrombin - immunology dabigatran blood platelets infection thrombin fibrin sepsis
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
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