Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

ABSTRACT Background There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of gut microbiota could explain several features of PD. Objective The objective of this study was to determine if PD involves dysbiosis of gut microbiome, disentangle effects...

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Bibliographic Details
Published in:	Movement disorders Vol. 32; no. 5; pp. 739 - 749
Main Authors:	Hill‐Burns, Erin M., Debelius, Justine W., Morton, James T., Wissemann, William T., Lewis, Matthew R., Wallen, Zachary D., Peddada, Shyamal D., Factor, Stewart A., Molho, Eric, Zabetian, Cyrus P., Knight, Rob, Payami, Haydeh
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.05.2017
Subjects:	Abundance Age Factors Anticholinergics Antiparkinson Agents - therapeutic use Bifidobacterium - genetics Carbidopa - therapeutic use Case-Control Studies Catechol Catechol O-methyltransferase Catechol O-Methyltransferase Inhibitors - therapeutic use Cholinergic Antagonists - therapeutic use confounding Confounding Factors, Epidemiologic Demography Deoxyribonucleic acid Diet Digestive system DNA DNA sequencing Drug Combinations Dysbacteriosis Dysbiosis - epidemiology Dysbiosis - microbiology Female Fruit functional pathways Gastrointestinal Microbiome - genetics Gastrointestinal tract gut microbiome Humans Intestinal microflora Lactobacillaceae - genetics Levodopa Levodopa - therapeutic use Male medications Methyltransferase Microbiota Movement disorders Neurodegenerative diseases Parkinson Disease - drug therapy Parkinson Disease - epidemiology Parkinson Disease - microbiology Parkinson's disease Pasteurellaceae - genetics Plants Risk Factors RNA, Ribosomal, 16S - genetics rRNA 16S Sex Factors United States - epidemiology Vegetables Verrucomicrobia - genetics Xenobiotics United States confounding Parkinson's disease gut microbiome functional pathways medications
ISSN:	0885-3185, 1531-8257
Online Access:	Get full text
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