Spinal Cord Atrophy Predicts Progressive Disease in Relapsing Multiple Sclerosis

Objective A major challenge in multiple sclerosis (MS) research is the understanding of silent progression and Progressive MS. Using a novel method to accurately capture upper cervical cord area from legacy brain MRI scans we aimed to study the role of spinal cord and brain atrophy for silent progre...

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Bibliographic Details
Published in:	Annals of neurology Vol. 91; no. 2; pp. 268 - 281
Main Authors:	Bischof, Antje, Papinutto, Nico, Keshavan, Anisha, Rajesh, Anand, Kirkish, Gina, Zhang, Xinheng, Mallott, Jacob M., Asteggiano, Carlo, Sacco, Simone, Gundel, Tristan J., Zhao, Chao, Stern, William A., Caverzasi, Eduardo, Zhou, Yifan, Gomez, Refujia, Ragan, Nicholas R., Santaniello, Adam, Zhu, Alyssa H., Juwono, Jeremy, Bevan, Carolyn J., Bove, Riley M., Crabtree, Elizabeth, Gelfand, Jeffrey M., Goodin, Douglas S., Graves, Jennifer S., Green, Ari J., Oksenberg, Jorge R., Waubant, Emmanuelle, Wilson, Michael R., Zamvil, Scott S., Cree, Bruce A. C., Hauser, Stephen L., Henry, Roland G.
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.02.2022 Wiley Subscription Services, Inc
Subjects:	Adult Atrophy Brain Brain - diagnostic imaging Brain - pathology Conversion Deceleration Disease Progression Female Foramen Magnum - diagnostic imaging Foramen Magnum - pathology Humans Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging Multiple Sclerosis, Relapsing-Remitting - pathology Predictive Value of Tests Prognosis Prospective Studies Spinal cord Spinal Cord - diagnostic imaging Spinal Cord - pathology
ISSN:	0364-5134, 1531-8249, 1531-8249
Online Access:	Get full text
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