Lin28 reprograms inner ear glia to a neuronal fate

Sensorineural hearing loss is irreversible and can be caused by loss of auditory neurons. Regeneration of neural cells from endogenous cells may offer a future tool to restore the auditory circuit and to enhance the performance of implantable hearing devices. Neurons and glial cells in the periphera...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Jg. 38; H. 7; S. 890 - 903
Hauptverfasser:	Kempfle, Judith S., Luu, Ngoc‐Nhi C., Petrillo, Marco, Al‐Asad, Reef, Zhang, Andrea, Edge, Albert S. B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 01.07.2020 Oxford University Press
Schlagworte:	Animals Brain damage Brain stem Cell proliferation Circuits Cochlea Conversion Ear Ear, Inner - physiology Glial cells glial conversion Hearing Hearing aids Hearing loss Hearing Loss, Central - metabolism Hearing protection Immunohistochemistry Inner ear Markers Mice mouse models Myelin proteolipid protein Nervous system Neural Stem Cells Neuroglia - metabolism Neuronal-glial interactions Neurons Neurons - metabolism Ouabain Peripheral nervous system Peripheral neuropathy Progenitor cells Regeneration Stem cells Surgical implants Transgenic mice mouse models glial conversion inner ear neural stem cells regeneration
ISSN:	1066-5099, 1549-4918, 1549-4918
Online-Zugang:	Volltext
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