Cytoplasmic functions of long noncoding RNAs

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found throughout the cell that lack protein‐coding function. Their functions are closely linked to their interaction with RNA‐binding proteins (RBPs) and nucleic acids. Nuclear lncRNAs have been studied extensively, revealing...

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Vydáno v:Wiley interdisciplinary reviews. RNA Ročník 9; číslo 3; s. e1471 - n/a
Hlavní autoři: Noh, Ji Heon, Kim, Kyoung Mi, McClusky, Waverly G., Abdelmohsen, Kotb, Gorospe, Myriam
Médium: Journal Article
Jazyk:angličtina
Vydáno: Hoboken, USA John Wiley & Sons, Inc 01.05.2018
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Témata:
Animals
circRNA
Cytoplasm - genetics
Gene regulation
Humans
lncRNA
Localization
miRNA
mRNA stability
mRNA turnover
noncoding RNA
Nucleotides
post‐transcriptional gene regulation
Protein Stability
Protein turnover
Proteins
ribonucleoprotein complexes
Riboswitches
RNA Stability
RNA transport
RNA, Long Noncoding
RNA, Messenger
RNA-mediated interference
Signal Transduction
Transcription
post-transcriptional gene regulation
miRNA
lncRNA
noncoding RNA
circRNA
ribonucleoprotein complexes
ISSN:1757-7004, 1757-7012, 1757-7012
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Popis
Shrnutí:Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found throughout the cell that lack protein‐coding function. Their functions are closely linked to their interaction with RNA‐binding proteins (RBPs) and nucleic acids. Nuclear lncRNAs have been studied extensively, revealing complexes with structural and regulatory roles that enable gene organization and control transcription. Cytoplasmic lncRNAs are less well understood, but accumulating evidence indicates that they also form complexes with diverse structural and regulatory functions. Here, we review our current knowledge of cytoplasmic lncRNAs and the different levels of gene regulation controlled by cytoplasmic lncRNA complexes, including mRNA turnover, translation, protein stability, sponging of cytosolic factors, and modulation of signaling pathways. We conclude by discussing areas of future study needed to elucidate comprehensively the biology of lncRNAs, to further understand the impact of lncRNAs on physiology and design lncRNA‐centered therapeutic strategies. This article is categorized under: RNA Export and Localization > RNA Localization Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications Different levels of regulation of gene expression by cytoplasmic lncRNAs. Cytoplasmic lncRNAs can (clockwise from top): alter the stability and translation of mRNAs, activate signaling molecules, affect organelle function, modulate the stability of specific proteins, and serve as decoys for cytosolic factors.
Bibliografie:ObjectType-Article-1
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ISSN:1757-7004
1757-7012
1757-7012
DOI:10.1002/wrna.1471