Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization

The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). Optical coherence tomography angiography was performed using a 100-kHz SS-OCT instrument and a 68-kHz SD-OCTA instr...

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Veröffentlicht in:Investigative ophthalmology & visual science Jg. 58; H. 3; S. 1499 - 1505
Hauptverfasser: Miller, Andrew R., Roisman, Luiz, Zhang, Qinqin, Zheng, Fang, Rafael de Oliveira Dias, Joao, Yehoshua, Zohar, Schaal, Karen B., Feuer, William, Gregori, Giovanni, Chu, Zhongdi, Chen, Chieh-Li, Kubach, Sophie, An, Lin, Stetson, Paul F., Durbin, Mary K., Wang, Ruikang K., Rosenfeld, Philip J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States The Association for Research in Vision and Ophthalmology 01.03.2017
Schlagworte:
Aged
Aged, 80 and over
Choroid - blood supply
Choroid - pathology
Choroidal Neovascularization - pathology
Choroidal Neovascularization - physiopathology
Female
Fluorescein Angiography - methods
Fundus Oculi
Humans
Male
Middle Aged
Prospective Studies
Reproducibility of Results
Retina
Tomography, Optical Coherence - methods
Visual Acuity
ISSN:1552-5783, 0146-0404, 1552-5783
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Zusammenfassung:The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). Optical coherence tomography angiography was performed using a 100-kHz SS-OCT instrument and a 68-kHz SD-OCTA instrument (Carl Zeiss Meditec, Inc.). Both 3 × 3- and 6 × 6-mm2 scans were obtained on both instruments. The 3 × 3-mm2 SS-OCTA scans consisted of 300 A-scans per B-scan at 300 B-scan positions, and the SD-OCTA scans consisted of 245 A-scans at 245 B-scan positions. The 6 × 6-mm2 SS-OCTA scans consisted of 420 A-scans per B-scan at 420 B-scan positions, and the SD-OCTA scans consisted of 350 A-scans and 350 B-scan positions. B-scans were repeated four times at each position in the 3 × 3-mm2 scans and twice in the 6 × 6-mm2 scans. Choroidal neovascularization was excluded if not fully contained within the 3 × 3-mm2 scans. The same algorithm was used to detect CNV on both instruments. Two graders outlined the CNV, and the lesion areas were compared between instruments. Twenty-seven consecutive eyes from 23 patients were analyzed. For the 3 × 3-mm2 scans, the mean lesion areas for the SS-OCTA and SD-OCTA instruments were 1.17 and 1.01 mm2, respectively (P = 0.047). For the 6 × 6-mm2 scans, the mean lesion areas for the SS-OCTA and SD-OCTA instruments were 1.24 and 0.74 mm2 (P = 0.003). The areas of CNV tended to be larger when imaged with SS-OCTA than with SD-OCTA, and this difference was greater for the 6 × 6-mm2 scans.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.16-20969