Regulation of early lung morphogenesis: questions, facts and controversies

During early respiratory system development, the foregut endoderm gives rise to the tracheal and lung cell progenitors. Through branching morphogenesis, and in coordination with vascular development, a tree-like structure of epithelial tubules forms and differentiates to produce the airways and alve...

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Veröffentlicht in:Development (Cambridge) Jg. 133; H. 9; S. 1611
Hauptverfasser: Cardoso, Wellington V, Lü, Jining
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.05.2006
Schlagworte:
Animals
Cell Differentiation
Embryonic Induction
Endoderm - cytology
Endoderm - physiology
Gene Expression Regulation, Developmental
Intercellular Signaling Peptides and Proteins - metabolism
Lung - embryology
Lung - metabolism
Models, Biological
Morphogenesis
Mutation
Neovascularization, Physiologic
Organogenesis
Pulmonary Alveoli - physiology
Signal Transduction
Trachea - embryology
ISSN:0950-1991
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Zusammenfassung:During early respiratory system development, the foregut endoderm gives rise to the tracheal and lung cell progenitors. Through branching morphogenesis, and in coordination with vascular development, a tree-like structure of epithelial tubules forms and differentiates to produce the airways and alveoli. Recent studies have implicated the fibroblast growth factor, sonic hedgehog, bone morphogenetic protein, retinoic acid and Wnt signaling pathways, and various transcription factors in regulating the initial stages of lung development. However, the precise roles of these molecules and how they interact in the developing lung is subject to debate. Here, we review early stages in lung development and highlight questions and controversies regarding their molecular regulation.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0950-1991
DOI:10.1242/dev.02310