Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-caus...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany, NY.) Jg. 9; H. 2; S. 419
Hauptverfasser: Quach, Austin, Levine, Morgan E, Tanaka, Toshiko, Lu, Ake T, Chen, Brian H, Ferrucci, Luigi, Ritz, Beate, Bandinelli, Stefania, Neuhouser, Marian L, Beasley, Jeannette M, Snetselaar, Linda, Wallace, Robert B, Tsao, Philip S, Absher, Devin, Assimes, Themistocles L, Stewart, James D, Li, Yun, Hou, Lifang, Baccarelli, Andrea A, Whitsel, Eric A, Horvath, Steve
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 14.02.2017
Schlagworte:
Aged
Aged, 80 and over
Aging - genetics
Aging - metabolism
Cohort Studies
Cross-Sectional Studies
Diet
Educational Status
Epigenesis, Genetic
Exercise
Female
Humans
Life Style
Middle Aged
DNA methylation
alcohol intake
aging
diet
fish intake
epigenetic clock
lifestyle
ISSN:1945-4589, 1945-4589
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-cause mortality, chronic conditions, and age-related functional decline. We analyze cross-sectional data from 4,173 postmenopausal female participants from the Women's Health Initiative, as well as 402 male and female participants from the Italian cohort study, Invecchiare nel Chianti.Extrinsic epigenetic age acceleration (EEAA) exhibits significant associations with fish intake (p=0.02), moderate alcohol consumption (p=0.01), education (p=3x10 ), BMI (p=0.01), and blood carotenoid levels (p=1x10 )-an indicator of fruit and vegetable consumption, whereas intrinsic epigenetic age acceleration (IEAA) is associated with poultry intake (p=0.03) and BMI (p=0.05). Both EEAA and IEAA were also found to relate to indicators of metabolic syndrome, which appear to mediate their associations with BMI. Metformin-the first-line medication for the treatment of type 2 diabetes-does not delay epigenetic aging in this observational study. Finally, longitudinal data suggests that an increase in BMI is associated with increase in both EEAA and IEAA.Overall, the epigenetic age analysis of blood confirms the conventional wisdom regarding the benefits of eating a high plant diet with lean meats, moderate alcohol consumption, physical activity, and education, as well as the health risks of obesity and metabolic syndrome.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101168