Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

Reprogramming of somatic cells into a pluripotent state is known to be accompanied by extensive restructuring of mitochondria and switch in metabolic requirements. Here we utilized Leber's hereditary optic neuropathy (LHON) as a mitochondrial disease model to study the effects of homoplasmic mt...

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Vydané v:	Aging (Albany, NY.) Ročník 8; číslo 5; s. 945
Hlavní autori:	Hung, Sandy S C, Van Bergen, Nicole J, Jackson, Stacey, Liang, Helena, Mackey, David A, Hernández, Damián, Lim, Shiang Y, Hewitt, Alex W, Trounce, Ian, Pébay, Alice, Wong, Raymond C B
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.05.2016
Predmet:	Cellular Reprogramming DNA, Mitochondrial Fibroblasts - metabolism Humans Induced Pluripotent Stem Cells - metabolism Mitochondria - metabolism Optic Atrophy, Hereditary, Leber - metabolism Organelle Biogenesis Oxidative Phosphorylation Leber's hereditary optic neuropathy induced pluripotent stem cells mitochondria oxidative phosphorylation cellular reprogramming
ISSN:	1945-4589, 1945-4589
On-line prístup:	Zistit podrobnosti o prístupe
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