Vibrational biospectroscopy characterizes biochemical differences between cell types used for toxicological investigations and identifies alterations induced by environmental contaminants

The use of cell‐based assays is essential in reducing the number of vertebrates used in the investigation of chemical toxicities and in regulatory toxicology assessment. An important factor in obtaining meaningful results that can be accurately extrapolated is the use of biologically appropriate cel...

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Vydané v:	Environmental toxicology and chemistry Ročník 36; číslo 11; s. 3127 - 3137
Hlavní autori:	Heys, Kelly A., Shore, Richard F., Pereira, M. Glória, Martin, Francis L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Oxford University Press 01.11.2017
Predmet:	Anas platyrhynchos Animal Testing Alternatives Animals Anseriformes Biochemical composition Biochemistry Biological effects Biospectroscopy Biotechnology Biphenyl Cell Line - drug effects Cell Line - metabolism Cell lines Cell‐specific differences chemical composition Congeners Contaminants Deoxyribonucleic acid DNA Environmental Pollutants - toxicity Exposure Fibroblasts Fourier transform infrared spectroscopy Fourier transforms Halogenated Diphenyl Ethers - toxicity Humans Infrared analysis Infrared reflection Infrared spectroscopy Lipids Macromolecules Mallard fibroblasts MCF-7 Cells - drug effects MCF-7 Cells - metabolism MCF‐7 cells Multivariate Analysis Nucleic acids PCB pollution Polybrominated diphenyl ethers Polychlorinated biphenyls Polychlorinated Biphenyls - toxicity Proteins Regulatory toxicology Skin Spectra Spectral alterations Spectroscopy Spectroscopy, Fourier Transform Infrared Spectrum analysis staining Toxicity Tests - methods Toxicology Vertebrates Cell-specific differences MCF-7 cells Spectral alterations Biospectroscopy Regulatory toxicology Mallard fibroblasts
ISSN:	0730-7268, 1552-8618, 1552-8618
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