Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells

In animals, adaptation to changes in cellular oxygen levels is coordinated largely by 2-oxoglutarate-dependent prolyl-hydroxylase domain (PHD) dioxygenase family members, which regulate the stability of their hypoxia-inducible factor (HIF) substrates to promote expression of genes that adapt cells t...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 299; H. 9; S. 105156
Hauptverfasser:	Tian, Ya-Min, Holdship, Philip, To, Trang Quynh, Ratcliffe, Peter J., Keeley, Thomas P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.09.2023 American Society for Biochemistry and Molecular Biology
Schlagworte:	ADO Animals Cysteine - metabolism dioxygenase HIF hydroxylase Hydroxylation Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mammals - metabolism Oxygen - metabolism PHD Procollagen-Proline Dioxygenase - metabolism sensing Signal Transduction hypoxia sensing HIF dioxygenase HPRT ADO hydroxylase PHD PCO
ISSN:	0021-9258, 1083-351X, 1083-351X
Online-Zugang:	Volltext
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