Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases

Deposition of α-synuclein fibrils is implicated in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), while in vivo detection of α-synuclein pathologies in these illnesses has been challenging. Here, we have developed a small-molecule ligand, C05-05, for visualizing α-synuclein depos...

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Vydané v:	Neuron (Cambridge, Mass.) Ročník 112; číslo 15; s. 2540
Hlavní autori:	Endo, Hironobu, Ono, Maiko, Takado, Yuhei, Matsuoka, Kiwamu, Takahashi, Manami, Tagai, Kenji, Kataoka, Yuko, Hirata, Kosei, Takahata, Keisuke, Seki, Chie, Kokubo, Naomi, Fujinaga, Masayuki, Mori, Wakana, Nagai, Yuji, Mimura, Koki, Kumata, Katsushi, Kikuchi, Tatsuya, Shimozawa, Aki, Mishra, Sushil K, Yamaguchi, Yoshiki, Shimizu, Hiroshi, Kakita, Akiyoshi, Takuwa, Hiroyuki, Shinotoh, Hitoshi, Shimada, Hitoshi, Kimura, Yasuyuki, Ichise, Masanori, Suhara, Tetsuya, Minamimoto, Takafumi, Sahara, Naruhiko, Kawamura, Kazunori, Zhang, Ming-Rong, Hasegawa, Masato, Higuchi, Makoto
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 07.08.2024
Predmet:	dementia with Lewy bodies propagation mouse model marmoset model intravital two-photon microscopy multiple system atrophy PET Parkinson’s disease in vivo α-synuclein
ISSN:	1097-4199, 1097-4199
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