Gut microbiota is associated with adiposity markers and probiotics may impact specific genera

Purpose It has been suggested that restoring gut microbiota alterations with probiotics represents a potential clinical target for the treatment of gut microbiota-related diseases, such as obesity. Here, we apply 16S rDNA microbiota profiling to establish which bacteria in the human gut are associat...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:European journal of nutrition Ročník 59; číslo 4; s. 1751 - 1762
Hlavní autori: Gomes, Aline Corado, Hoffmann, Christian, Mota, João Felipe
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2020
Springer Nature B.V
Predmet:
Adipose tissue
Adiposity
Adult
antioxidant enzymes
Antioxidants
bacteria
Bifidobacterium animalis subsp. lactis
Bifidobacterium bifidum
Body composition
Body fat
body mass index
Body weight
Chemistry
Chemistry and Materials Science
Clinical trials
Clostridiaceae
Cluster Analysis
Cross-Sectional Studies
diet
Dietary supplements
digestive system
Double-Blind Method
fat intake
Feces - microbiology
Female
Gastrointestinal Microbiome
glycohemoglobin
Gut microbiota
Hemoglobin
Humans
Inflammation
Interleukin 1
Interleukin 10
Interleukin 6
Intestinal microflora
intestinal microorganisms
Lactobacillus acidophilus
Lactobacillus casei
Lactococcus lactis
microbiome
Microbiomes
Microbiota
Nutrition
Obesity
Original Contribution
Overweight
Overweight - blood
Overweight - microbiology
Probiotics
Probiotics - metabolism
Probiotics - pharmacology
protein intake
ribosomal DNA
Risk factors
rRNA 16S
sequence analysis
tumor necrosis factor-alpha
Tumor necrosis factor-α
women
Yogurt
Gut microbiota
Obesity
Probiotics
Body composition
ISSN:1436-6207, 1436-6215, 1436-6215
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Purpose It has been suggested that restoring gut microbiota alterations with probiotics represents a potential clinical target for the treatment of gut microbiota-related diseases, such as obesity. Here, we apply 16S rDNA microbiota profiling to establish which bacteria in the human gut are associated with obesity and cardiometabolic risk factors, and to evaluate whether probiotic supplementation modulates gut microbiota. Methods We evaluated the effects of a probiotic mixture (2 × 10 10 CFU/day of Lactobacillus acidophilus LA-14, Lactobacillus casei LC-11, Lactococcus lactis LL-23, Bifidobacterium bifidum BB-06, and Bifidobacterium lactis BL-4) in 32 overweight or obese women in a double-blind, randomized, placebo-controlled study. Using 16S rDNA sequencing, we characterized fecal samples and investigated the relationships between microbiome data and diet, body composition, antioxidant enzymes, and inflammatory profile. In addition, we characterized the degree of variation among fecal communities after the intervention. Results BMI, weight, fat mass, lean mass, conicity index, protein intake, monounsaturated fat intake, glycated hemoglobin, TNF-α, and IL6/IL10 were significantly correlated with microbiome composition. The candidate division TM7 was strongly associated with all adiposity markers and Clostridiaceae associated negatively with TNF-α. The family Clostridiaceae increased and TM7 tended to decrease after the probiotic mixture supplementation. Subjects were clustered according to body composition, and a higher proportion of TM7 was observed in those with higher adiposity. Conclusions Ecosystem-wide analysis of probiotic use effects on the gut microbiota revealed a genera specific influence, and one of which (TM7) represents a promising novel target for obesity treatment. Trial registration number U1111-1137-4566.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ObjectType-Undefined-3
ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-019-02034-0