Correlates of Protection for Cholera

Abstract A correlate of protection (CoP) is a measured adaptive immune response to vaccination or infection that is associated with protection against disease. However, the degree to which a CoP can serve as a surrogate end point for vaccine efficacy should depend on the robustness of this associati...

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Published in:The Journal of infectious diseases Vol. 224; no. Supplement_7; pp. S732 - S737
Main Authors: Iyer, Anita S, Harris, Jason B
Format: Journal Article
Language:English
Published: US Oxford University Press 20.12.2021
Subjects:
Adaptive Immunity
Antibodies, Bacterial - immunology
Cholera - prevention & control
Cholera Toxin - immunology
Cholera Vaccines - adverse effects
Cholera Vaccines - immunology
Humans
Vaccine Efficacy
Vibrio cholerae - immunology
Vibrio cholerae O1 - immunology
cholera vaccines
correlates of protection
cholera
ISSN:0022-1899, 1537-6613, 1537-6613
Online Access:Get full text
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Summary:Abstract A correlate of protection (CoP) is a measured adaptive immune response to vaccination or infection that is associated with protection against disease. However, the degree to which a CoP can serve as a surrogate end point for vaccine efficacy should depend on the robustness of this association. While cholera toxin is a dominant target of the human antibody response to Vibrio cholerae infection, antitoxin responses are not associated with long-term immunity, and are not effective CoPs for cholera. Instead, protection appears to be mediated by functional antibodies that target the O-polysaccharide coated V. cholerae outer membrane. Vibriocidal antibodies, which are complement-dependent bactericidal antibodies, remain the most accepted CoP for cholera and are used as surrogate end points in some vaccine studies. However, the association between vibriocidal antibody titers and immunity is not absolute, and they are unlikely to reflect a mechanistic correlate of protection against cholera.
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ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiab497