Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single-cell transcriptional pr...

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Vydané v:	Journal of investigative dermatology Ročník 138; číslo 4; s. 811
Hlavní autori:	Philippeos, Christina, Telerman, Stephanie B, Oulès, Bénédicte, Pisco, Angela O, Shaw, Tanya J, Elgueta, Raul, Lombardi, Giovanna, Driskell, Ryan R, Soldin, Mark, Lynch, Magnus D, Watt, Fiona M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.04.2018
Predmet:	Animals Animals, Newborn Cells, Cultured Dermis - metabolism Dermis - pathology Extracellular Matrix - genetics Extracellular Matrix - metabolism Fibroblasts - metabolism Fibroblasts - pathology Flow Cytometry Gene Expression Regulation, Developmental Humans Mice Polymerase Chain Reaction RNA - genetics Signal Transduction Wnt Proteins - biosynthesis Wnt Proteins - genetics Wound Healing - genetics
ISSN:	1523-1747, 1523-1747
On-line prístup:	Zistit podrobnosti o prístupe
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