Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single-cell transcriptional pr...

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Veröffentlicht in:	Journal of investigative dermatology Jg. 138; H. 4; S. 811
Hauptverfasser:	Philippeos, Christina, Telerman, Stephanie B, Oulès, Bénédicte, Pisco, Angela O, Shaw, Tanya J, Elgueta, Raul, Lombardi, Giovanna, Driskell, Ryan R, Soldin, Mark, Lynch, Magnus D, Watt, Fiona M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2018
Schlagworte:	Animals Animals, Newborn Cells, Cultured Dermis - metabolism Dermis - pathology Extracellular Matrix - genetics Extracellular Matrix - metabolism Fibroblasts - metabolism Fibroblasts - pathology Flow Cytometry Gene Expression Regulation, Developmental Humans Mice Polymerase Chain Reaction RNA - genetics Signal Transduction Wnt Proteins - biosynthesis Wnt Proteins - genetics Wound Healing - genetics
ISSN:	1523-1747, 1523-1747
Online-Zugang:	Weitere Angaben
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