State-of-the-art review on AL amyloidosis in Western Countries: Epidemiology, health economics, risk assessment and therapeutic management of a rare disease

Amyloidosis is the term to define a broad array of rare protein misfolding syndromes. Among them, light chain (AL) amyloidosis is the most common, affecting roughly 10 people per million/year. The core purpose of the present literature review is to shed light on the academic and clinical knowledge o...

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Veröffentlicht in:	Blood reviews Jg. 59; S. 101040
Hauptverfasser:	Sabinot, Alice, Ghetti, Gianni, Pradelli, Lorenzo, Bellucci, Stefania, Lausi, Antonella, Palladini, Giovanni
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.05.2023
Schlagworte:	AL amyloidosis Amyloidosis - diagnosis Amyloidosis - epidemiology Amyloidosis - etiology Epidemiology Humans Immunoglobulin Light-chain Amyloidosis - diagnosis Immunoglobulin Light-chain Amyloidosis - epidemiology Immunoglobulin Light-chain Amyloidosis - therapy Light-chain amyloidosis PRISMA guidelines Quality of Life Rare Diseases Risk Assessment Risk-staging Systematic literature review cTnI PR PS BNP LDex CyBorDM dLFC Epidemiology HD-Dex UK cTnT Risk-staging PFS US PRISMA guidelines BorD AL amyloidosis Bor MS AL IT ER ES MDex EU SF36-v1 AT SF36-v2 NCI DaraLDex ASCT IMiD NL Systematic literature review SES N/A RS NR CyBorD FR L N QoL HDM SF36 BU NT-proBNP T NRes MPredDex VGPR DaraBorDex CA GE SR eGFR GI OS SW CI GR m MPred PMP TBor y Light-chain amyloidosis HD HR-QoL
ISSN:	0268-960X, 1532-1681, 1532-1681
Online-Zugang:	Volltext
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Zusammenfassung:	Amyloidosis is the term to define a broad array of rare protein misfolding syndromes. Among them, light chain (AL) amyloidosis is the most common, affecting roughly 10 people per million/year. The core purpose of the present literature review is to shed light on the academic and clinical knowledge on the condition, encompassing its i) epidemiology, ii) economic burden, and iii) quality of life consequences. The areas of interest are Europe and North America. Literature search was primarily performed on Embase® and finally integrated with additional, deemed eligible, sources. Pre-defined PICOS criteria were employed for the inclusion and exclusion processes. A total of 64 studies were comprehensively included in the current literature review as compliant with the inclusion criteria. The results were presented according to the outcomes of interest and eventually triangulated and compared to available literature studies. A broad picture on the main aspects of AL amyloidosis is delivered.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0268-960X 1532-1681 1532-1681
DOI:	10.1016/j.blre.2023.101040