State-of-the-art review on AL amyloidosis in Western Countries: Epidemiology, health economics, risk assessment and therapeutic management of a rare disease

Amyloidosis is the term to define a broad array of rare protein misfolding syndromes. Among them, light chain (AL) amyloidosis is the most common, affecting roughly 10 people per million/year. The core purpose of the present literature review is to shed light on the academic and clinical knowledge o...

Full description

Saved in:
Bibliographic Details
Published in:Blood reviews Vol. 59; p. 101040
Main Authors: Sabinot, Alice, Ghetti, Gianni, Pradelli, Lorenzo, Bellucci, Stefania, Lausi, Antonella, Palladini, Giovanni
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.05.2023
Subjects:
AL amyloidosis
Amyloidosis - diagnosis
Amyloidosis - epidemiology
Amyloidosis - etiology
Epidemiology
Humans
Immunoglobulin Light-chain Amyloidosis - diagnosis
Immunoglobulin Light-chain Amyloidosis - epidemiology
Immunoglobulin Light-chain Amyloidosis - therapy
Light-chain amyloidosis
PRISMA guidelines
Quality of Life
Rare Diseases
Risk Assessment
Risk-staging
Systematic literature review
cTnI
PR
PS
BNP
LDex
CyBorDM
dLFC
Epidemiology
HD-Dex
UK
cTnT
Risk-staging
PFS
US
PRISMA guidelines
BorD
AL amyloidosis
Bor
MS
AL
IT
ER
ES
MDex
EU
SF36-v1
AT
SF36-v2
NCI
DaraLDex
ASCT
IMiD
NL
Systematic literature review
SES
N/A
RS
NR
CyBorD
FR
L
N
QoL
HDM
SF36
BU
NT-proBNP
T
NRes
MPredDex
VGPR
DaraBorDex
CA
GE
SR
eGFR
GI
OS
SW
CI
GR
m
MPred
PMP
TBor
y
Light-chain amyloidosis
HD
HR-QoL
ISSN:0268-960X, 1532-1681, 1532-1681
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amyloidosis is the term to define a broad array of rare protein misfolding syndromes. Among them, light chain (AL) amyloidosis is the most common, affecting roughly 10 people per million/year. The core purpose of the present literature review is to shed light on the academic and clinical knowledge on the condition, encompassing its i) epidemiology, ii) economic burden, and iii) quality of life consequences. The areas of interest are Europe and North America. Literature search was primarily performed on Embase® and finally integrated with additional, deemed eligible, sources. Pre-defined PICOS criteria were employed for the inclusion and exclusion processes. A total of 64 studies were comprehensively included in the current literature review as compliant with the inclusion criteria. The results were presented according to the outcomes of interest and eventually triangulated and compared to available literature studies. A broad picture on the main aspects of AL amyloidosis is delivered.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0268-960X
1532-1681
1532-1681
DOI:10.1016/j.blre.2023.101040