Circulating tumor DNA status and dynamics predict recurrence in patients with resected extrahepatic cholangiocarcinoma
Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longi...
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| Published in: | Journal of hepatology Vol. 82; no. 5; pp. 861 - 870 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01.05.2025
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| ISSN: | 0168-8278, 1600-0641, 1600-0641 |
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| Abstract | Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compared the efficacy of adjuvant capecitabine (CAP) vs. gemcitabine plus cisplatin (GemCis).
Between July 2017 and November 2020, 101 patients were randomized 1:1 to receive GemCis (n = 50) or CAP (n = 51). Efficacy outcomes were analyzed with an extended follow-up of 19 months from the previous report. From a biomarker cohort of 89 patients, longitudinal plasma samples (n = 254) were prospectively collected post-surgery before ACT, and on-ACT at 12 and 24 weeks from cycle 1 day 1 (C1D1). ctDNA was evaluated using a personalized, tumor-informed, 16-plex PCR next-generation sequencing assay and was correlated with clinical outcomes.
In the extended follow-up analysis, median disease-free survival (DFS) and overall survival did not significantly differ between the CAP and GemCis groups. Significantly inferior DFS was associated with ctDNA positivity before ACT (hazard ratio [HR] 1.8; p = 0.029), on-ACT at 12 weeks from C1D1 (HR 7.72; p <0.001), on-ACT at 24 weeks from C1D1 (HR 5.24; p <0.001), and anytime post-surgery (HR 3.81; p <0.001). Analysis of pre-treatment to on-treatment ctDNA dynamics revealed that serially ctDNA-negative patients exhibited a significantly longer DFS compared to those with sustained ctDNA positivity (HR 6.7; p <0.001) or those who turned ctDNA positive (HR 5.8; p <0.001).
In patients with resected extrahepatic cholangiocarcinoma, ctDNA status and dynamics predicted recurrence during adjuvant therapy, and may help optimize clinical decision-making.
The findings from this study highlight the critical role of ctDNA as a prognostic biomarker and monitoring tool for patients with resected extrahepatic cholangiocarcinoma. By demonstrating the superiority of ctDNA to predict disease recurrence compared to conventional biomarkers such as cancer antigen 19-9 and carcinoembryonic antigen, this study underscores its potential in guiding decision-making during adjuvant chemotherapy. These results may be crucial to refine post-surgical treatment strategies and improve patient outcomes. The practical application of ctDNA monitoring could lead to more personalized treatment approaches, enabling timely interventions based on molecular residual disease status.
NCT03079427.
[Display omitted]
•No DFS or OS difference between adjuvant CAP and GemCis in resected LN+ eCCA.•Tumor-informed ctDNA status predicts recurrence in patients with resected eCCA.•ctDNA status outperforms CA 19-9 and CEA in predicting survival outcomes.•Personalized ctDNA monitoring helps optimize adjuvant therapy decision-making. |
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| AbstractList | Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compared the efficacy of adjuvant capecitabine (CAP) vs. gemcitabine plus cisplatin (GemCis).
Between July 2017 and November 2020, 101 patients were randomized 1:1 to receive GemCis (n = 50) or CAP (n = 51). Efficacy outcomes were analyzed with an extended follow-up of 19 months from the previous report. From a biomarker cohort of 89 patients, longitudinal plasma samples (n = 254) were prospectively collected post-surgery before ACT, and on-ACT at 12 and 24 weeks from cycle 1 day 1 (C1D1). ctDNA was evaluated using a personalized, tumor-informed, 16-plex PCR next-generation sequencing assay and was correlated with clinical outcomes.
In the extended follow-up analysis, median disease-free survival (DFS) and overall survival did not significantly differ between the CAP and GemCis groups. Significantly inferior DFS was associated with ctDNA positivity before ACT (hazard ratio [HR] 1.8; p = 0.029), on-ACT at 12 weeks from C1D1 (HR 7.72; p <0.001), on-ACT at 24 weeks from C1D1 (HR 5.24; p <0.001), and anytime post-surgery (HR 3.81; p <0.001). Analysis of pre-treatment to on-treatment ctDNA dynamics revealed that serially ctDNA-negative patients exhibited a significantly longer DFS compared to those with sustained ctDNA positivity (HR 6.7; p <0.001) or those who turned ctDNA positive (HR 5.8; p <0.001).
In patients with resected extrahepatic cholangiocarcinoma, ctDNA status and dynamics predicted recurrence during adjuvant therapy, and may help optimize clinical decision-making.
The findings from this study highlight the critical role of ctDNA as a prognostic biomarker and monitoring tool for patients with resected extrahepatic cholangiocarcinoma. By demonstrating the superiority of ctDNA to predict disease recurrence compared to conventional biomarkers such as cancer antigen 19-9 and carcinoembryonic antigen, this study underscores its potential in guiding decision-making during adjuvant chemotherapy. These results may be crucial to refine post-surgical treatment strategies and improve patient outcomes. The practical application of ctDNA monitoring could lead to more personalized treatment approaches, enabling timely interventions based on molecular residual disease status.
NCT03079427.
[Display omitted]
•No DFS or OS difference between adjuvant CAP and GemCis in resected LN+ eCCA.•Tumor-informed ctDNA status predicts recurrence in patients with resected eCCA.•ctDNA status outperforms CA 19-9 and CEA in predicting survival outcomes.•Personalized ctDNA monitoring helps optimize adjuvant therapy decision-making. Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compared the efficacy of adjuvant capecitabine (CAP) vs. gemcitabine plus cisplatin (GemCis). Between July 2017 and November 2020, 101 patients were randomized 1:1 to receive GemCis (n = 50) or CAP (n = 51). Efficacy outcomes were analyzed with an extended follow-up of 19 months from the previous report. From a biomarker cohort of 89 patients, longitudinal plasma samples (n = 254) were prospectively collected post-surgery before ACT, and on-ACT at 12 and 24 weeks from cycle 1 day 1 (C1D1). ctDNA was evaluated using a personalized, tumor-informed, 16-plex PCR next-generation sequencing assay and was correlated with clinical outcomes. In the extended follow-up analysis, median disease-free survival (DFS) and overall survival did not significantly differ between the CAP and GemCis groups. Significantly inferior DFS was associated with ctDNA positivity before ACT (hazard ratio [HR] 1.8; p = 0.029), on-ACT at 12 weeks from C1D1 (HR 7.72; p <0.001), on-ACT at 24 weeks from C1D1 (HR 5.24; p <0.001), and anytime post-surgery (HR 3.81; p <0.001). Analysis of pre-treatment to on-treatment ctDNA dynamics revealed that serially ctDNA-negative patients exhibited a significantly longer DFS compared to those with sustained ctDNA positivity (HR 6.7; p <0.001) or those who turned ctDNA positive (HR 5.8; p <0.001). In patients with resected extrahepatic cholangiocarcinoma, ctDNA status and dynamics predicted recurrence during adjuvant therapy, and may help optimize clinical decision-making. The findings from this study highlight the critical role of ctDNA as a prognostic biomarker and monitoring tool for patients with resected extrahepatic cholangiocarcinoma. By demonstrating the superiority of ctDNA to predict disease recurrence compared to conventional biomarkers such as cancer antigen 19-9 and carcinoembryonic antigen, this study underscores its potential in guiding decision-making during adjuvant chemotherapy. These results may be crucial to refine post-surgical treatment strategies and improve patient outcomes. The practical application of ctDNA monitoring could lead to more personalized treatment approaches, enabling timely interventions based on molecular residual disease status. NCT03079427. Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compares the efficacy of adjuvant capecitabine (CAP) vs. gemcitabine plus cisplatin (GemCis).BACKGROUND & AIMSSurgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compares the efficacy of adjuvant capecitabine (CAP) vs. gemcitabine plus cisplatin (GemCis).Between July 2017 and November 2020, 101 patients were randomized 1:1 to receive GemCis (n = 50) or CAP (n = 51). Efficacy outcomes were analyzed with an extended follow-up of 19 months from the previous report. From a biomarker cohort of 89 patients, longitudinal plasma samples (n = 254) were prospectively collected post-surgery before ACT, and on-ACT at 12 and 24 weeks from cycle 1 day 1 (C1D1). ctDNA was evaluated using a personalized, tumor-informed, 16-plex PCR next-generation sequencing assay and was correlated with clinical outcomes.METHODSBetween July 2017 and November 2020, 101 patients were randomized 1:1 to receive GemCis (n = 50) or CAP (n = 51). Efficacy outcomes were analyzed with an extended follow-up of 19 months from the previous report. From a biomarker cohort of 89 patients, longitudinal plasma samples (n = 254) were prospectively collected post-surgery before ACT, and on-ACT at 12 and 24 weeks from cycle 1 day 1 (C1D1). ctDNA was evaluated using a personalized, tumor-informed, 16-plex PCR next-generation sequencing assay and was correlated with clinical outcomes.In the extended follow-up analysis, median disease-free survival (DFS) and overall survival did not significantly differ between the CAP and GemCis groups. Significantly inferior DFS was associated with ctDNA positivity before ACT (hazard ratio [HR] 1.8; p = 0.029), on-ACT at 12 weeks from C1D1 (HR 7.72; p <0.001), on-ACT at 24 weeks from C1D1 (HR 5.24; p <0.001), and anytime post-surgery (HR 3.81; p <0.001). Analysis of pre-treatment to on-treatment ctDNA dynamics revealed that serially ctDNA-negative patients exhibited a significantly longer DFS compared to those with sustained ctDNA positivity (HR 6.7; p <0.001) or those who turned ctDNA positive (HR 5.8; p <0.001).RESULTSIn the extended follow-up analysis, median disease-free survival (DFS) and overall survival did not significantly differ between the CAP and GemCis groups. Significantly inferior DFS was associated with ctDNA positivity before ACT (hazard ratio [HR] 1.8; p = 0.029), on-ACT at 12 weeks from C1D1 (HR 7.72; p <0.001), on-ACT at 24 weeks from C1D1 (HR 5.24; p <0.001), and anytime post-surgery (HR 3.81; p <0.001). Analysis of pre-treatment to on-treatment ctDNA dynamics revealed that serially ctDNA-negative patients exhibited a significantly longer DFS compared to those with sustained ctDNA positivity (HR 6.7; p <0.001) or those who turned ctDNA positive (HR 5.8; p <0.001).In patients with resected extrahepatic cholangiocarcinoma, ctDNA status and dynamics predicted recurrence during adjuvant therapy, and may help optimize clinical decision-making.CONCLUSIONIn patients with resected extrahepatic cholangiocarcinoma, ctDNA status and dynamics predicted recurrence during adjuvant therapy, and may help optimize clinical decision-making.The findings from this study highlight the critical role of ctDNA as a prognostic biomarker and monitoring tool for patients with resected extrahepatic cholangiocarcinoma. By demonstrating the superiority of ctDNA to predict disease recurrence compared to conventional biomarkers such as cancer antigen 19-9 and carcinoembryonic antigen, this study underscores its potential in guiding decision-making during adjuvant chemotherapy. These results may be crucial to refine post-surgical treatment strategies and improve patient outcomes. The practical application of ctDNA monitoring could lead to more personalized treatment approaches, enabling timely interventions based on molecular residual disease status.IMPACT AND IMPLICATIONSThe findings from this study highlight the critical role of ctDNA as a prognostic biomarker and monitoring tool for patients with resected extrahepatic cholangiocarcinoma. By demonstrating the superiority of ctDNA to predict disease recurrence compared to conventional biomarkers such as cancer antigen 19-9 and carcinoembryonic antigen, this study underscores its potential in guiding decision-making during adjuvant chemotherapy. These results may be crucial to refine post-surgical treatment strategies and improve patient outcomes. The practical application of ctDNA monitoring could lead to more personalized treatment approaches, enabling timely interventions based on molecular residual disease status.NCT03079427.CLINICAL TRIAL REGISTRATION NUMBERNCT03079427. |
| Author | Ryoo, Baek-Yeol Lee, Ji Sung Jeong, Jae Ho Hwang, Dae Wook Lee, Sang Soo Jurdi, Adham Yoo, Changhoon Chon, Hong Jae Sharma, Shruti Moon, Deog-Bog Spickard, Erik Liu, Minetta C. Palsuledesai, Charuta C. Song, Tae Jun Kim, Ki-Hun Renner, Derrick Dutta, Punashi Kim, Kyu-pyo Oh, Dongwook Malhotra, Meenakshi Lee, Seonmin Lee, Jae Hoon Rivero-Hinojosa, Samuel Lee, Myung Ah Jeong, Hyehyun Laliotis, George |
| Author_xml | – sequence: 1 givenname: Changhoon orcidid: 0000-0002-1451-8455 surname: Yoo fullname: Yoo, Changhoon email: yooc@amc.seoul.kr organization: Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 2 givenname: Hyehyun surname: Jeong fullname: Jeong, Hyehyun organization: Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 3 givenname: Jae Ho surname: Jeong fullname: Jeong, Jae Ho organization: Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 4 givenname: Kyu-pyo surname: Kim fullname: Kim, Kyu-pyo organization: Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 5 givenname: Seonmin surname: Lee fullname: Lee, Seonmin organization: University of Ulsan Digestive Disease Research Center, Seoul, Korea – sequence: 6 givenname: Baek-Yeol orcidid: 0000-0002-9052-833X surname: Ryoo fullname: Ryoo, Baek-Yeol organization: Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 7 givenname: Dae Wook orcidid: 0000-0002-1749-038X surname: Hwang fullname: Hwang, Dae Wook organization: Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea – sequence: 8 givenname: Jae Hoon surname: Lee fullname: Lee, Jae Hoon organization: Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea – sequence: 9 givenname: Deog-Bog surname: Moon fullname: Moon, Deog-Bog organization: Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea – sequence: 10 givenname: Ki-Hun surname: Kim fullname: Kim, Ki-Hun organization: Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea – sequence: 11 givenname: Sang Soo orcidid: 0000-0002-2762-9066 surname: Lee fullname: Lee, Sang Soo organization: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 12 givenname: Tae Jun surname: Song fullname: Song, Tae Jun organization: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 13 givenname: Dongwook surname: Oh fullname: Oh, Dongwook organization: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 14 givenname: Myung Ah orcidid: 0000-0002-1204-0574 surname: Lee fullname: Lee, Myung Ah organization: Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea – sequence: 15 givenname: Hong Jae orcidid: 0000-0002-6979-5812 surname: Chon fullname: Chon, Hong Jae organization: Department of Medical Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea – sequence: 16 givenname: Ji Sung surname: Lee fullname: Lee, Ji Sung organization: Department of Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea – sequence: 17 givenname: George orcidid: 0000-0001-9205-8258 surname: Laliotis fullname: Laliotis, George organization: Natera, Inc., Austin, TX, USA – sequence: 18 givenname: Samuel surname: Rivero-Hinojosa fullname: Rivero-Hinojosa, Samuel organization: Natera, Inc., Austin, TX, USA – sequence: 19 givenname: Erik orcidid: 0000-0002-5024-3559 surname: Spickard fullname: Spickard, Erik organization: Natera, Inc., Austin, TX, USA – sequence: 20 givenname: Derrick orcidid: 0000-0002-1349-8050 surname: Renner fullname: Renner, Derrick organization: Natera, Inc., Austin, TX, USA – sequence: 21 givenname: Punashi surname: Dutta fullname: Dutta, Punashi organization: Natera, Inc., Austin, TX, USA – sequence: 22 givenname: Charuta C. surname: Palsuledesai fullname: Palsuledesai, Charuta C. organization: Natera, Inc., Austin, TX, USA – sequence: 23 givenname: Shruti surname: Sharma fullname: Sharma, Shruti organization: Natera, Inc., Austin, TX, USA – sequence: 24 givenname: Meenakshi surname: Malhotra fullname: Malhotra, Meenakshi organization: Natera, Inc., Austin, TX, USA – sequence: 25 givenname: Adham orcidid: 0000-0002-2985-3053 surname: Jurdi fullname: Jurdi, Adham organization: Natera, Inc., Austin, TX, USA – sequence: 26 givenname: Minetta C. orcidid: 0000-0002-8206-5232 surname: Liu fullname: Liu, Minetta C. organization: Natera, Inc., Austin, TX, USA |
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| Cites_doi | 10.1016/S1470-2045(18)30915-X 10.1001/jamaoncol.2019.0528 10.5009/gnl15568 10.1038/s41591-022-02115-4 10.1200/JCO.2021.39.15_suppl.4103 10.1016/S0140-6736(22)02038-4 10.3390/ijms24087512 10.1016/j.pan.2018.09.004 10.3892/ol.2023.13733 10.1097/HEP.0000000000000046 10.1158/1078-0432.CCR-21-2404 10.1158/1078-0432.CCR-18-3663 10.1016/j.ygyno.2022.09.004 10.1038/nrgastro.2016.51 10.1053/j.gastro.2011.12.005 10.1038/s41575-020-0310-z 10.1200/JCO.21.02568 10.1038/s41598-020-65720-8 |
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| References | Banales, Cardinale, Carpino (bib4) May 2016; 13 Huffman, Aushev, Budde (bib10) Dec 2022; 6 Loupakis, Sharma, Derouazi (bib20) 2021; 5 (bib6) March 1, 2023 Kasi, Budde, Dayyani (bib22) 2021; 39 Tsen, Barbara, Rosenkranz (bib18) 2018; 18 Primrose, Fox, Palmer (bib7) May 2019; 20 Jeong, Kim, Jeong (bib8) May 1 2023; 77 Wang, Bi, Zhao (bib19) 2023; 25 Henriksen, Tarazona, Frydendahl (bib21) Feb 1 2022; 28 Kim, Park, Seo (bib17) 2020; 10 Kotani, Oki, Nakamura (bib9) Jan 2023; 29 Bridgewater, Fletcher, Palmer (bib14) Jun 20 2022; 40 Coombes, Page, Salari (bib12) Jul 15 2019; 25 Nakachi, Ikeda, Konishi (bib15) Jan 21 2023; 401 Hou, Chapman, Kalashnikova (bib11) Sep 15 2022; 167 Banales, Marin, Lamarca (bib2) Sep 2020; 17 Andersen, Spee, Blechacz (bib5) Apr 2012; 142 Kim, Yi, Lee (bib16) Apr 19 2023; 24 Blechacz (bib3) Jan 15 2017; 11 Patel, Benipal (bib1) Jan 25 2019; 11 Reinert, Henriksen, Christensen (bib13) Aug 1 2019; 5 Patel (10.1016/j.jhep.2024.10.043_bib1) 2019; 11 Hou (10.1016/j.jhep.2024.10.043_bib11) 2022; 167 Kasi (10.1016/j.jhep.2024.10.043_bib22) 2021; 39 Jeong (10.1016/j.jhep.2024.10.043_bib8) 2023; 77 Tsen (10.1016/j.jhep.2024.10.043_bib18) 2018; 18 Henriksen (10.1016/j.jhep.2024.10.043_bib21) 2022; 28 Primrose (10.1016/j.jhep.2024.10.043_bib7) 2019; 20 Nakachi (10.1016/j.jhep.2024.10.043_bib15) 2023; 401 Banales (10.1016/j.jhep.2024.10.043_bib2) 2020; 17 Reinert (10.1016/j.jhep.2024.10.043_bib13) 2019; 5 Andersen (10.1016/j.jhep.2024.10.043_bib5) 2012; 142 Kim (10.1016/j.jhep.2024.10.043_bib16) 2023; 24 Kotani (10.1016/j.jhep.2024.10.043_bib9) 2023; 29 Bridgewater (10.1016/j.jhep.2024.10.043_bib14) 2022; 40 Kim (10.1016/j.jhep.2024.10.043_bib17) 2020; 10 (10.1016/j.jhep.2024.10.043_bib6) 2023 Huffman (10.1016/j.jhep.2024.10.043_bib10) 2022; 6 Banales (10.1016/j.jhep.2024.10.043_bib4) 2016; 13 Wang (10.1016/j.jhep.2024.10.043_bib19) 2023; 25 Coombes (10.1016/j.jhep.2024.10.043_bib12) 2019; 25 Blechacz (10.1016/j.jhep.2024.10.043_bib3) 2017; 11 Loupakis (10.1016/j.jhep.2024.10.043_bib20) 2021; 5 |
| References_xml | – volume: 11 start-page: 13 year: Jan 15 2017 end-page: 26 ident: bib3 article-title: Cholangiocarcinoma: current knowledge and new developments publication-title: Gut Liver – volume: 28 start-page: 507 year: Feb 1 2022 end-page: 517 ident: bib21 article-title: Circulating tumor DNA in stage III colorectal cancer, beyond minimal residual disease detection, toward assessment of adjuvant therapy efficacy and clinical behavior of recurrences publication-title: Clin Cancer Res – volume: 11 year: Jan 25 2019 ident: bib1 article-title: Incidence of cholangiocarcinoma in the USA from 2001 to 2015: a US cancer statistics analysis of 50 states publication-title: Cureus – volume: 142 start-page: 1021 year: Apr 2012 end-page: 1031 e15 ident: bib5 article-title: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors publication-title: Gastroenterology – volume: 167 start-page: 334 year: Sep 15 2022 end-page: 341 ident: bib11 article-title: Circulating tumor DNA monitoring for early recurrence detection in epithelial ovarian cancer publication-title: Gynecol Oncol – volume: 6 year: Dec 2022 ident: bib10 article-title: Analysis of circulating tumor DNA to predict risk of recurrence in patients with esophageal and gastric cancers publication-title: JCO Precis Oncol – volume: 77 start-page: 1540 year: May 1 2023 end-page: 1549 ident: bib8 article-title: Adjuvant gemcitabine plus cisplatin versus capecitabine in node-positive extrahepatic cholangiocarcinoma: the STAMP randomized trial publication-title: Hepatology – volume: 10 start-page: 8820 year: 2020 ident: bib17 article-title: Carbohydrate antigen 19-9 elevation without evidence of malignant or pancreatobiliary diseases publication-title: Sci Rep – volume: 25 start-page: 4255 year: Jul 15 2019 end-page: 4263 ident: bib12 article-title: Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence publication-title: Clin Cancer Res – volume: 5 year: 2021 ident: bib20 article-title: Detection of molecular residual disease using personalized circulating tumor DNA assay in patients with colorectal cancer undergoing resection of metastases publication-title: JCO Precis Oncol – year: March 1, 2023 ident: bib6 article-title: Survival rates for bile duct cancer publication-title: cancer.org – volume: 24 start-page: 7512 year: Apr 19 2023 ident: bib16 article-title: Targeting the sequences of circulating tumor DNA of cholangiocarcinomas and its applications and limitations in clinical practice publication-title: Int J Mol Sci – volume: 39 year: 2021 ident: bib22 article-title: Tumor-informed assessment of circulating tumor DNA and its incorporation into practice for patients with hepatobiliary cancers publication-title: J Clin Oncol – volume: 20 start-page: 663 year: May 2019 end-page: 673 ident: bib7 article-title: Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study publication-title: Lancet Oncol – volume: 401 start-page: 195 year: Jan 21 2023 end-page: 203 ident: bib15 article-title: Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial publication-title: Lancet – volume: 18 start-page: 862 year: 2018 end-page: 867 ident: bib18 article-title: Dilemma of elevated CA 19-9 in biliary pathology publication-title: Pancreatology – volume: 25 start-page: 147 year: 2023 ident: bib19 article-title: Prognostic significance of the preoperative alkaline phosphatase-to-albumin ratio in patients with hepatocellular carcinoma after hepatic resection publication-title: Oncol Lett – volume: 13 start-page: 261 year: May 2016 end-page: 280 ident: bib4 article-title: Expert consensus document: cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) publication-title: Nat Rev Gastroenterol Hepatol – volume: 17 start-page: 557 year: Sep 2020 end-page: 588 ident: bib2 article-title: Cholangiocarcinoma 2020: the next horizon in mechanisms and management publication-title: Nat Rev Gastroenterol Hepatol – volume: 5 start-page: 1124 year: Aug 1 2019 end-page: 1131 ident: bib13 article-title: Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages I to III colorectal cancer publication-title: JAMA Oncol – volume: 40 start-page: 2048 year: Jun 20 2022 end-page: 2057 ident: bib14 article-title: Long-term outcomes and exploratory analyses of the randomized phase III BILCAP study publication-title: J Clin Oncol – volume: 29 start-page: 127 year: Jan 2023 end-page: 134 ident: bib9 article-title: Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer publication-title: Nat Med – volume: 20 start-page: 663 issue: 5 year: 2019 ident: 10.1016/j.jhep.2024.10.043_bib7 article-title: Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(18)30915-X – volume: 5 start-page: 1124 issue: 8 year: 2019 ident: 10.1016/j.jhep.2024.10.043_bib13 article-title: Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages I to III colorectal cancer publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2019.0528 – volume: 11 issue: 1 year: 2019 ident: 10.1016/j.jhep.2024.10.043_bib1 article-title: Incidence of cholangiocarcinoma in the USA from 2001 to 2015: a US cancer statistics analysis of 50 states publication-title: Cureus – volume: 11 start-page: 13 issue: 1 year: 2017 ident: 10.1016/j.jhep.2024.10.043_bib3 article-title: Cholangiocarcinoma: current knowledge and new developments publication-title: Gut Liver doi: 10.5009/gnl15568 – volume: 29 start-page: 127 issue: 1 year: 2023 ident: 10.1016/j.jhep.2024.10.043_bib9 article-title: Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer publication-title: Nat Med doi: 10.1038/s41591-022-02115-4 – volume: 39 issue: Number 15_suppl year: 2021 ident: 10.1016/j.jhep.2024.10.043_bib22 article-title: Tumor-informed assessment of circulating tumor DNA and its incorporation into practice for patients with hepatobiliary cancers publication-title: J Clin Oncol doi: 10.1200/JCO.2021.39.15_suppl.4103 – volume: 401 start-page: 195 issue: 10372 year: 2023 ident: 10.1016/j.jhep.2024.10.043_bib15 article-title: Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial publication-title: Lancet doi: 10.1016/S0140-6736(22)02038-4 – volume: 6 year: 2022 ident: 10.1016/j.jhep.2024.10.043_bib10 article-title: Analysis of circulating tumor DNA to predict risk of recurrence in patients with esophageal and gastric cancers publication-title: JCO Precis Oncol – volume: 24 start-page: 7512 issue: 8 year: 2023 ident: 10.1016/j.jhep.2024.10.043_bib16 article-title: Targeting the sequences of circulating tumor DNA of cholangiocarcinomas and its applications and limitations in clinical practice publication-title: Int J Mol Sci doi: 10.3390/ijms24087512 – year: 2023 ident: 10.1016/j.jhep.2024.10.043_bib6 article-title: Survival rates for bile duct cancer publication-title: cancer.org – volume: 18 start-page: 862 issue: 8 year: 2018 ident: 10.1016/j.jhep.2024.10.043_bib18 article-title: Dilemma of elevated CA 19-9 in biliary pathology publication-title: Pancreatology doi: 10.1016/j.pan.2018.09.004 – volume: 25 start-page: 147 issue: 4 year: 2023 ident: 10.1016/j.jhep.2024.10.043_bib19 article-title: Prognostic significance of the preoperative alkaline phosphatase-to-albumin ratio in patients with hepatocellular carcinoma after hepatic resection publication-title: Oncol Lett doi: 10.3892/ol.2023.13733 – volume: 77 start-page: 1540 issue: 5 year: 2023 ident: 10.1016/j.jhep.2024.10.043_bib8 article-title: Adjuvant gemcitabine plus cisplatin versus capecitabine in node-positive extrahepatic cholangiocarcinoma: the STAMP randomized trial publication-title: Hepatology doi: 10.1097/HEP.0000000000000046 – volume: 28 start-page: 507 issue: 3 year: 2022 ident: 10.1016/j.jhep.2024.10.043_bib21 article-title: Circulating tumor DNA in stage III colorectal cancer, beyond minimal residual disease detection, toward assessment of adjuvant therapy efficacy and clinical behavior of recurrences publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-21-2404 – volume: 25 start-page: 4255 issue: 14 year: 2019 ident: 10.1016/j.jhep.2024.10.043_bib12 article-title: Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-18-3663 – volume: 167 start-page: 334 issue: 2 year: 2022 ident: 10.1016/j.jhep.2024.10.043_bib11 article-title: Circulating tumor DNA monitoring for early recurrence detection in epithelial ovarian cancer publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2022.09.004 – volume: 5 issue: PO.21 year: 2021 ident: 10.1016/j.jhep.2024.10.043_bib20 article-title: Detection of molecular residual disease using personalized circulating tumor DNA assay in patients with colorectal cancer undergoing resection of metastases publication-title: JCO Precis Oncol – volume: 13 start-page: 261 issue: 5 year: 2016 ident: 10.1016/j.jhep.2024.10.043_bib4 article-title: Expert consensus document: cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/nrgastro.2016.51 – volume: 142 start-page: 1021 issue: 4 year: 2012 ident: 10.1016/j.jhep.2024.10.043_bib5 article-title: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.12.005 – volume: 17 start-page: 557 issue: 9 year: 2020 ident: 10.1016/j.jhep.2024.10.043_bib2 article-title: Cholangiocarcinoma 2020: the next horizon in mechanisms and management publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/s41575-020-0310-z – volume: 40 start-page: 2048 issue: 18 year: 2022 ident: 10.1016/j.jhep.2024.10.043_bib14 article-title: Long-term outcomes and exploratory analyses of the randomized phase III BILCAP study publication-title: J Clin Oncol doi: 10.1200/JCO.21.02568 – volume: 10 start-page: 8820 issue: 1 year: 2020 ident: 10.1016/j.jhep.2024.10.043_bib17 article-title: Carbohydrate antigen 19-9 elevation without evidence of malignant or pancreatobiliary diseases publication-title: Sci Rep doi: 10.1038/s41598-020-65720-8 |
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| Title | Circulating tumor DNA status and dynamics predict recurrence in patients with resected extrahepatic cholangiocarcinoma |
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