Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis

Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic study of AD with deeply sequenced RNA-sequencing samples using long (126-bp) paired-end reads. In addition to the comparis...

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Veröffentlicht in:	Journal of investigative dermatology Jg. 139; H. 7; S. 1480
Hauptverfasser:	Tsoi, Lam C, Rodriguez, Elke, Degenhardt, Frauke, Baurecht, Hansjörg, Wehkamp, Ulrike, Volks, Natalie, Szymczak, Silke, Swindell, William R, Sarkar, Mrinal K, Raja, Kalpana, Shao, Shuai, Patrick, Matthew, Gao, Yilin, Uppala, Ranjitha, Perez White, Bethany E, Getsios, Spiro, Harms, Paul W, Maverakis, Emanual, Elder, James T, Franke, Andre, Gudjonsson, Johann E, Weidinger, Stephan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2019
Schlagworte:	Cohort Studies Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Gene Expression Profiling Humans Interleukin-13 - genetics Interleukin-13 - metabolism Interleukin-4 - metabolism Organ Specificity - genetics Psoriasis - genetics Psoriasis - immunology RNA - genetics RNA, Long Noncoding - genetics Sequence Analysis, RNA Signal Transduction Skin - metabolism Skin - pathology Th2 Cells - immunology Transcriptome
ISSN:	1523-1747, 1523-1747
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