MALDI-MS-based imaging of small molecules and proteins in tissues

The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled wit...

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Bibliographic Details
Published in:	Current opinion in chemical biology Vol. 11; no. 1; pp. 29 - 35
Main Authors:	Reyzer, Michelle L, Caprioli, Richard M
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.02.2007
Subjects:	Animals Biomarkers - analysis Cerebellum - chemistry Cerebellum - metabolism Cerebellum - pathology Humans Mice Neoplasms - chemistry Neoplasms - metabolism Neoplasms - pathology Neurosciences - methods Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Proteins - analysis Proteins - chemistry Proteins - metabolism Rats Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends Technology, Pharmaceutical - methods Tissue Distribution Tissue Extracts - analysis Tissue Extracts - chemistry Tissue Extracts - metabolism
ISSN:	1367-5931, 1879-0402
Online Access:	Get full text
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