MALDI-MS-based imaging of small molecules and proteins in tissues

The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled wit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in chemical biology Jg. 11; H. 1; S. 29 - 35
Hauptverfasser:	Reyzer, Michelle L, Caprioli, Richard M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.02.2007
Schlagworte:	Animals Biomarkers - analysis Cerebellum - chemistry Cerebellum - metabolism Cerebellum - pathology Humans Mice Neoplasms - chemistry Neoplasms - metabolism Neoplasms - pathology Neurosciences - methods Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Proteins - analysis Proteins - chemistry Proteins - metabolism Rats Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends Technology, Pharmaceutical - methods Tissue Distribution Tissue Extracts - analysis Tissue Extracts - chemistry Tissue Extracts - metabolism
ISSN:	1367-5931, 1879-0402
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled with excellent sensitivity and rapid analysis time, presents many potential advantages to a wide range of applications in diverse biological fields. Recent advances have shown how the technique can be applied to cancer research, neuroscience and pharmaceutical development. Examples include the use of unique protein profiles to classify human tumor tissues and predict patient outcomes, the discovery of protein changes in mouse cerebellum as a function of development, and the two-dimensional visualization of the distribution of a drug and first-pass metabolites in rat whole-body sections.
AbstractList	The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled with excellent sensitivity and rapid analysis time, presents many potential advantages to a wide range of applications in diverse biological fields. Recent advances have shown how the technique can be applied to cancer research, neuroscience and pharmaceutical development. Examples include the use of unique protein profiles to classify human tumor tissues and predict patient outcomes, the discovery of protein changes in mouse cerebellum as a function of development, and the two-dimensional visualization of the distribution of a drug and first-pass metabolites in rat whole-body sections.The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled with excellent sensitivity and rapid analysis time, presents many potential advantages to a wide range of applications in diverse biological fields. Recent advances have shown how the technique can be applied to cancer research, neuroscience and pharmaceutical development. Examples include the use of unique protein profiles to classify human tumor tissues and predict patient outcomes, the discovery of protein changes in mouse cerebellum as a function of development, and the two-dimensional visualization of the distribution of a drug and first-pass metabolites in rat whole-body sections. The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled with excellent sensitivity and rapid analysis time, presents many potential advantages to a wide range of applications in diverse biological fields. Recent advances have shown how the technique can be applied to cancer research, neuroscience and pharmaceutical development. Examples include the use of unique protein profiles to classify human tumor tissues and predict patient outcomes, the discovery of protein changes in mouse cerebellum as a function of development, and the two-dimensional visualization of the distribution of a drug and first-pass metabolites in rat whole-body sections.
Author	Caprioli, Richard M Reyzer, Michelle L
Author_xml	– sequence: 1 givenname: Michelle L surname: Reyzer fullname: Reyzer, Michelle L – sequence: 2 givenname: Richard M surname: Caprioli fullname: Caprioli, Richard M email: r.caprioli@vanderbilt.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17185024$$D View this record in MEDLINE/PubMed
BookMark	eNqFkT1PwzAURS1UBOXjDzCgTGwJfnbi2BJLVT6lIgZgthznBblKnBKnSPx7XBWExFCm5-Ec-_neIzLxvUdCzoBmQEFcLjNbrUzGKBUZQEZ5sUemIEuV0pyySTxzUaaF4nBIjkJY0ggyWRyQQyhBFpTlUzJ7nC2uH9LH57QyAevEdebN-bekb5LQmbZNur5Fu24xJMbXyWroR3Q-JM4nowthjeGE7DemDXj6PY_J6-3Ny_w-XTzdPcxni9TmBYwpNAqZaWQtOZa8qWpqgFnBS5XzignAEhljpSqkyqXljeVFXguAQqhKUYH8mFxs7407vMd3R925YLFtjcd-HbSQSjGew78gKJFLYDKC59_guuqw1qsh_n741D_pRIBtATv0IQzY_CJUbyrQS72pQG8q0AA6VhAl-UeybjSj6_04GNfuVq-2KsYcPxwOOliH3mLtBrSjrnu3S_8CznSetA
CitedBy_id	crossref_primary_10_1016_j_talanta_2019_03_117 crossref_primary_10_1021_jasms_4c00405 crossref_primary_10_1002_pmic_200700629 crossref_primary_10_1586_14789450_5_3_435 crossref_primary_10_1007_s00216_014_8300_z crossref_primary_10_1016_j_pharmthera_2011_12_007 crossref_primary_10_1007_s00216_017_0336_4 crossref_primary_10_1007_s00216_015_8744_9 crossref_primary_10_1155_2016_9162074 crossref_primary_10_1016_j_trac_2023_117412 crossref_primary_10_1186_2049_3002_1_4 crossref_primary_10_3109_00498254_2011_587550 crossref_primary_10_1097_QAI_0b013e3182986ff8 crossref_primary_10_1007_s00216_016_9793_4 crossref_primary_10_1116_1_3397736 crossref_primary_10_1016_j_jprot_2011_10_001 crossref_primary_10_1016_j_biochi_2007_07_024 crossref_primary_10_1002_jms_1716 crossref_primary_10_1002_jms_1958 crossref_primary_10_1038_s41598_022_19365_4 crossref_primary_10_1111_j_1365_313X_2009_04012_x crossref_primary_10_1016_j_jprot_2012_04_005 crossref_primary_10_1080_05704928_2016_1207659 crossref_primary_10_1016_j_ab_2013_11_013 crossref_primary_10_1016_j_bbapap_2016_11_003 crossref_primary_10_1073_pnas_0711730105 crossref_primary_10_1039_c3cs35389c crossref_primary_10_1160_TH10_12_0812 crossref_primary_10_1016_j_jprot_2010_02_010 crossref_primary_10_1039_D5AY00426H crossref_primary_10_1007_s00216_025_05930_z crossref_primary_10_1002_jms_3068 crossref_primary_10_1007_s00216_011_5003_6 crossref_primary_10_1016_j_ygcen_2018_02_012 crossref_primary_10_4155_bio_10_201 crossref_primary_10_1002_rcm_3981 crossref_primary_10_1586_14789450_5_3_393 crossref_primary_10_3109_10409238_2013_806887 crossref_primary_10_1016_j_bbalip_2017_04_006 crossref_primary_10_1007_s00418_008_0469_9 crossref_primary_10_1002_mas_20288 crossref_primary_10_1002_pmic_200701142 crossref_primary_10_1021_jasms_4c00145 crossref_primary_10_3168_jds_2025_26891 crossref_primary_10_1586_14789450_5_3_413 crossref_primary_10_1038_s41598_017_03375_8 crossref_primary_10_1016_j_bios_2018_11_033 crossref_primary_10_1186_s13020_022_00586_8 crossref_primary_10_1016_j_bbalip_2011_05_006 crossref_primary_10_1016_j_chemphyslip_2018_07_002 crossref_primary_10_1007_s00216_012_5988_5 crossref_primary_10_1007_s00216_010_3850_1 crossref_primary_10_1007_s00216_018_1199_z crossref_primary_10_1016_j_trac_2008_01_006 crossref_primary_10_3390_plants11091234 crossref_primary_10_1007_s00418_013_1127_4 crossref_primary_10_1038_nprot_2011_388 crossref_primary_10_1016_j_jasms_2008_05_006 crossref_primary_10_1007_s00216_011_4990_7 crossref_primary_10_1016_j_bbalip_2014_03_003 crossref_primary_10_1002_dneu_20623 crossref_primary_10_3390_metabo9070135 crossref_primary_10_1146_annurev_biochem_060409_092612 crossref_primary_10_1080_10408347_2025_2482143 crossref_primary_10_1016_j_ymeth_2009_07_009 crossref_primary_10_1002_bmc_1528 crossref_primary_10_1002_mas_20182 crossref_primary_10_1016_j_ijms_2025_117512 crossref_primary_10_1038_nmeth1094 crossref_primary_10_1002_mas_21449 crossref_primary_10_1002_rcm_3934 crossref_primary_10_1016_j_chroma_2012_08_072 crossref_primary_10_1016_j_jprot_2013_03_013 crossref_primary_10_1007_s10126_009_9202_5 crossref_primary_10_1007_s00216_021_03476_4 crossref_primary_10_1586_14789450_5_6_841 crossref_primary_10_1007_s00418_013_1097_6 crossref_primary_10_1007_s13361_010_0003_x crossref_primary_10_1016_j_ab_2008_04_004 crossref_primary_10_1007_s00216_014_8174_0 crossref_primary_10_1002_jms_1078 crossref_primary_10_1186_1746_4811_7_21 crossref_primary_10_1002_rcm_3253 crossref_primary_10_1002_rcm_9476 crossref_primary_10_1016_j_semnephrol_2007_09_002 crossref_primary_10_5012_bkcs_2013_34_6_1708 crossref_primary_10_1053_j_gastro_2015_07_058 crossref_primary_10_1016_j_drudis_2009_02_007 crossref_primary_10_1038_srep29970 crossref_primary_10_1038_labinvest_2014_156 crossref_primary_10_1126_scitranslmed_aan6361 crossref_primary_10_1039_b915674g crossref_primary_10_1007_s00441_013_1714_7 crossref_primary_10_1021_jasms_2c00015 crossref_primary_10_1039_b920572a crossref_primary_10_1007_s00216_011_4696_x crossref_primary_10_4155_bio_14_89 crossref_primary_10_1002_nadc_200744633 crossref_primary_10_1111_j_1600_0625_2011_01289_x crossref_primary_10_4236_jasmi_2012_23021 crossref_primary_10_1016_j_micron_2017_01_004 crossref_primary_10_1186_s12931_019_1144_5 crossref_primary_10_1002_jms_1245 crossref_primary_10_1002_rcm_7226 crossref_primary_10_1016_j_aca_2025_344613 crossref_primary_10_1016_j_talanta_2013_05_050 crossref_primary_10_1038_nm_3937 crossref_primary_10_4155_bio_11_282 crossref_primary_10_1002_mas_20243 crossref_primary_10_1039_C9RA08096A crossref_primary_10_1007_s00216_011_4814_9 crossref_primary_10_1007_s11356_021_12688_1 crossref_primary_10_1016_j_bcp_2013_08_026 crossref_primary_10_1208_s12248_008_9016_9 crossref_primary_10_1021_ja9081827 crossref_primary_10_1002_jms_1254 crossref_primary_10_1016_j_drudis_2011_10_002 crossref_primary_10_1371_journal_pone_0011411 crossref_primary_10_1080_08940886_2017_1338418 crossref_primary_10_1002_rcm_5135 crossref_primary_10_1016_j_jchromb_2011_03_037 crossref_primary_10_1002_pmic_200800364 crossref_primary_10_1002_jcb_21875 crossref_primary_10_1016_j_aca_2008_06_017 crossref_primary_10_1246_cl_180329 crossref_primary_10_1016_j_talanta_2016_10_055 crossref_primary_10_1002_rcm_5021 crossref_primary_10_1007_s13361_011_0227_4 crossref_primary_10_1002_rcm_9981 crossref_primary_10_1039_c1an00008j crossref_primary_10_1586_14789450_4_3_347 crossref_primary_10_1002_mas_21510 crossref_primary_10_4155_bio_14_63
Cites_doi	10.1158/0008-5472.CAN-04-2231 10.1021/ac051534r 10.1021/pr049975z 10.1016/S1044-0305(03)00288-5 10.1002/jms.1041 10.1016/j.mad.2004.09.032 10.1038/86573 10.1021/ac00171a028 10.1158/1078-0432.CCR-0927-3 10.1002/rcm.1290020802 10.1002/rcm.2397 10.1016/j.jasms.2005.02.026 10.1021/ac0351264 10.1158/1078-0432.CCR-06-0264 10.1126/science.2675315 10.1016/0168-1176(87)87041-6 10.1021/ac060788p 10.1002/jms.525 10.1002/anie.200502362 10.1016/S0140-6736(03)14068-8 10.1021/ac970888i 10.1158/0008-5472.CAN-04-3016 10.1021/ac0514669 10.1021/pr050281f 10.1002/rcm.1725 10.1002/jnr.20590 10.1074/mcp.M600119-MCP200 10.1021/ac050868d
ContentType	Journal Article
Copyright	2006 Elsevier Ltd
Copyright_xml	– notice: 2006 Elsevier Ltd
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 P64 7X8
DOI	10.1016/j.cbpa.2006.11.035
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Engineering Research Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Chemistry
EISSN	1879-0402
EndPage	35
ExternalDocumentID	17185024 10_1016_j_cbpa_2006_11_035 S1367593106001918
Genre	Research Support, U.S. Gov't, Non-P.H.S Review Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: CA86243 – fundername: NIGMS NIH HHS grantid: GM58008
GroupedDBID	--- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARLI AATCM AAXUO ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACNNM ACRLP ADBBV ADECG ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGRDE AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCB SCC SDF SDG SDP SES SEW SPC SPCBC SSK SSP SSU SSZ T5K ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO ADVLN AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS BNPGV CGR CUY CVF ECM EIF NPM SSH 7QO 8FD FR3 P64 7X8
ID	FETCH-LOGICAL-c451t-1f9e2af8d83e73fbd0a12c637943b261e7e2227958948c3fc354d611569b906e3
ISICitedReferencesCount	188
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000244807600005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1367-5931
IngestDate	Sun Nov 09 10:21:08 EST 2025 Tue Oct 07 09:33:09 EDT 2025 Thu Jun 12 16:03:24 EDT 2025 Tue Nov 18 21:19:31 EST 2025 Sat Nov 29 07:02:30 EST 2025 Fri Feb 23 02:27:48 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c451t-1f9e2af8d83e73fbd0a12c637943b261e7e2227958948c3fc354d611569b906e3
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3
PMID	17185024
PQID	19648128
PQPubID	23462
PageCount	7
ParticipantIDs	proquest_miscellaneous_68992341 proquest_miscellaneous_19648128 pubmed_primary_17185024 crossref_primary_10_1016_j_cbpa_2006_11_035 crossref_citationtrail_10_1016_j_cbpa_2006_11_035 elsevier_sciencedirect_doi_10_1016_j_cbpa_2006_11_035
PublicationCentury	2000
PublicationDate	2007-02-01
PublicationDateYYYYMMDD	2007-02-01
PublicationDate_xml	– month: 02 year: 2007 text: 2007-02-01 day: 01
PublicationDecade	2000
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Current opinion in chemical biology
PublicationTitleAlternate	Curr Opin Chem Biol
PublicationYear	2007
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Reyzer, Caldwell, Dugger, Forbes, Ritter, Guix, Arteaga, Caprioli (bib12) 2004; 64 Wang H-YJ, Jackson, McEuen, Woods (bib26) 2005; 77 Aerni, Cornett, Caprioli (bib13) 2006; 78 Schwartz, Weil, Thompson, Shyr, Moore, Toms, Johnson, Caprioli (bib10) 2005; 65 Fenn, Mann, Meng, Wong, Whitehouse (bib4) 1989; 246 Stoeckli, Chaurand, Hallahan, Caprioli (bib6) 2001; 7 Lemaire, Tabet, Ducoroy, Hendra, Salzet, Fournier (bib28) 2006; 78 Chaurand, Schwartz, Billheimer, Xu, Crecelius, Caprioli (bib16) 2004; 76 Amann, Chaurand, Gonzalez, Mobley, Massion, Carbone, Caprioli (bib15) 2006; 12 Crecelius, Cornett, Caprioli, Williams, Dawant, Bodenheimer (bib18) 2005; 16 Laurent, Levinson, Schwartz, Harrington, Markey, Caprioli, Levitt (bib19) 2005; 81 Khatib-Shahidi, Andersson, Herman, Gillespie, Caprioli (bib24) 2006; 78 Yanagisawa, Shyr, Xu, Massion, Larsen, White, Roberts, Edgerton, Gonzalez, Nadaf (bib11) 2003; 362 Bunch, Clench, Richards (bib25) 2004; 18 Reyzer, Hsieh, Ng, Korfmacher, Caprioli (bib22) 2003; 38 Wiseman, Puolitaival, Takats, Cooks, Caprioli (bib27) 2005; 44 Kruse, Sweedler (bib17) 2003; 14 Skold, Svensson, Nilsson, Zhang, Nydahl, Caprioli, Svenningsson, Andren (bib20) 2006; 5 Karas, Hillenkamp (bib2) 1988; 60 Holle, Haase, Kayser, Höhndorf (bib29) 2006; 41 Tanaka, Waki, Ido, Akita, Yoshida, Yoshida (bib3) 1988; 2 Campa, Wang, Howard, Fitzgerald, Patz, Edward (bib7) 2003; 63 Yang, Guo, Diehl, DeSouza, Rodrigues, Romaschin, Colgan, Siu (bib8) 2004; 3 Hsieh, Casale, Fukuda, Chen, Knemeyer, Wingate, Morrison, Korfmacher (bib23) 2006; 20 Schwartz, Weil, Johnson, Toms, Caprioli (bib9) 2004; 10 Cornett, Mobley, Dias, Andersson, Arteaga, Sanders, Caprioli (bib14) 2006; 5 Caprioli, Farmer, Gile (bib5) 1997; 69 Rohner, Staab, Stoeckli (bib21) 2005; 126 Karas, Bachmann, Bahr, Hillenkamp (bib1) 1987; 78 Chaurand (10.1016/j.cbpa.2006.11.035_bib16) 2004; 76 Laurent (10.1016/j.cbpa.2006.11.035_bib19_1) 2005; 81 Reyzer (10.1016/j.cbpa.2006.11.035_bib22) 2003; 38 Fenn (10.1016/j.cbpa.2006.11.035_bib4) 1989; 246 Kruse (10.1016/j.cbpa.2006.11.035_bib17) 2003; 14 Karas (10.1016/j.cbpa.2006.11.035_bib1) 1987; 78 Cornett (10.1016/j.cbpa.2006.11.035_bib14) 2006; 5 Yang (10.1016/j.cbpa.2006.11.035_bib8) 2004; 3 Schwartz (10.1016/j.cbpa.2006.11.035_bib10_1) 2005; 65 Lemaire (10.1016/j.cbpa.2006.11.035_bib28) 2006; 78 Skold (10.1016/j.cbpa.2006.11.035_bib20) 2006; 5 Rohner (10.1016/j.cbpa.2006.11.035_bib21) 2005; 126 Stoeckli (10.1016/j.cbpa.2006.11.035_bib6) 2001; 7 Tanaka (10.1016/j.cbpa.2006.11.035_bib3) 1988; 2 Campa (10.1016/j.cbpa.2006.11.035_bib7) 2003; 63 Amann (10.1016/j.cbpa.2006.11.035_bib15) 2006; 12 Schwartz (10.1016/j.cbpa.2006.11.035_bib9) 2004; 10 Karas (10.1016/j.cbpa.2006.11.035_bib2) 1988; 60 Reyzer (10.1016/j.cbpa.2006.11.035_bib12) 2004; 64 Wiseman (10.1016/j.cbpa.2006.11.035_bib27) 2005; 44 Crecelius (10.1016/j.cbpa.2006.11.035_bib18_1) 2005; 16 Aerni (10.1016/j.cbpa.2006.11.035_bib13) 2006; 78 Wang H-YJ (10.1016/j.cbpa.2006.11.035_bib26) 2005; 77 Khatib-Shahidi (10.1016/j.cbpa.2006.11.035_bib24_1) 2006; 78 Bunch (10.1016/j.cbpa.2006.11.035_bib25) 2004; 18 Holle (10.1016/j.cbpa.2006.11.035_bib29_1) 2006; 41 Hsieh (10.1016/j.cbpa.2006.11.035_bib23_1) 2006; 20 Yanagisawa (10.1016/j.cbpa.2006.11.035_bib11) 2003; 362 Caprioli (10.1016/j.cbpa.2006.11.035_bib5) 1997; 69
References_xml	– volume: 60 start-page: 2299 year: 1988 end-page: 2301 ident: bib2 article-title: Laser desorption ionization of proteins with molecular masses exceeding 10, 000 daltons publication-title: Anal Chem – volume: 77 start-page: 6682 year: 2005 end-page: 6686 ident: bib26 article-title: Localization and analyses of small drug molecules in rat brain tissue sections publication-title: Anal Chem – volume: 65 start-page: 7674 year: 2005 end-page: 7681 ident: bib10 article-title: Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry publication-title: Cancer Res – volume: 5 start-page: 1975 year: 2006 end-page: 1983 ident: bib14 article-title: A novel histology directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancer publication-title: Molecular and Cellular Proteomics – volume: 12 start-page: 5142 year: 2006 end-page: 5150 ident: bib15 article-title: Selective profiling of proteins in lung cancer cells from fine-needle aspirates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry publication-title: Clin Cancer Res – volume: 78 start-page: 809 year: 2006 end-page: 819 ident: bib28 article-title: Solid ionic matrixes for direct tissue analysis and MALDI imaging publication-title: Anal Chem – volume: 69 start-page: 4751 year: 1997 end-page: 4760 ident: bib5 article-title: Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS publication-title: Anal Chem – volume: 76 start-page: 1145 year: 2004 end-page: 1155 ident: bib16 article-title: Integrating histology and imaging mass spectrometry publication-title: Anal Chem – volume: 2 start-page: 151 year: 1988 end-page: 153 ident: bib3 article-title: Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry publication-title: Rapid Commun Mass Spectrom – volume: 44 start-page: 7094 year: 2005 end-page: 7097 ident: bib27 article-title: Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization publication-title: Angew Chem Int Ed Engl – volume: 78 start-page: 827 year: 2006 end-page: 834 ident: bib13 article-title: Automated acoustic matrix deposition for MALDI sample preparation publication-title: Anal Chem – volume: 3 start-page: 636 year: 2004 end-page: 643 ident: bib8 article-title: Protein expression profiling of endometrial malignancies reveals a new tumor marker: chaperonin 10 publication-title: J Proteome Res – volume: 14 start-page: 752 year: 2003 end-page: 759 ident: bib17 article-title: Spatial profiling invertebrate ganglia using MALDI MS publication-title: J Am Soc Mass Spectrom – volume: 20 start-page: 965 year: 2006 end-page: 972 ident: bib23 article-title: Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue publication-title: Rapid Commun Mass Spectrom – volume: 362 start-page: 433 year: 2003 end-page: 439 ident: bib11 article-title: Proteomic patterns of tumour subsets in non-small-cell lung cancer publication-title: Lancet – volume: 81 start-page: 613 year: 2005 end-page: 621 ident: bib19 article-title: Direct profiling of the cerebellum by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a methodological study in postnatal and adult mouse publication-title: J Neurosci Res – volume: 246 start-page: 64 year: 1989 end-page: 71 ident: bib4 article-title: Electrospray ionization for mass spectrometry of large biomolecules publication-title: Science – volume: 78 start-page: 53 year: 1987 end-page: 68 ident: bib1 article-title: Matrix-assisted ultraviolet laser desorption of non-volatile compounds publication-title: Int J Mass Spectrom Ion Process – volume: 64 start-page: 9093 year: 2004 end-page: 9100 ident: bib12 article-title: Early changes in protein expression detected by mass spectrometry predict tumor response to molecular therapeutics publication-title: Cancer Res – volume: 5 start-page: 262 year: 2006 end-page: 269 ident: bib20 article-title: Decreased striatal levels of PEP-19 following MPTP lesion in the mouse publication-title: J Proteome Res – volume: 41 start-page: 705 year: 2006 end-page: 716 ident: bib29 article-title: Optimizing UV laser focus profiles for improved MALDI performance publication-title: J Mass Spectrom – volume: 78 start-page: 6448 year: 2006 end-page: 6456 ident: bib24 article-title: Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry publication-title: Anal. Chem. – volume: 10 start-page: 981 year: 2004 end-page: 987 ident: bib9 article-title: Protein profiling in brain tumors using mass spectrometry: feasibility of a new technique for the analysis of protein expression publication-title: Clin Cancer Res – volume: 38 start-page: 1081 year: 2003 end-page: 1092 ident: bib22 article-title: Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry publication-title: J Mass Spectrom – volume: 16 start-page: 1093 year: 2005 end-page: 1099 ident: bib18 article-title: Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry publication-title: J Am Soc Mass Spectrom – volume: 7 start-page: 493 year: 2001 end-page: 496 ident: bib6 article-title: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues publication-title: Nat Med – volume: 18 start-page: 3051 year: 2004 end-page: 3060 ident: bib25 article-title: Determination of pharmaceutical compounds in skin by imaging matrix-assisted laser desorption/ionisation mass spectrometry publication-title: Rapid Commun Mass Spectrom – volume: 126 start-page: 177 year: 2005 end-page: 185 ident: bib21 article-title: MALDI mass spectrometric imaging of biological tissue sections publication-title: Mech Ageing Dev – volume: 63 start-page: 1652 year: 2003 end-page: 1656 ident: bib7 article-title: Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin A as potential molecular targets in non-small cell lung cancer publication-title: Cancer Res – volume: 64 start-page: 9093 year: 2004 ident: 10.1016/j.cbpa.2006.11.035_bib12 article-title: Early changes in protein expression detected by mass spectrometry predict tumor response to molecular therapeutics publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2231 – volume: 78 start-page: 827 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib13 article-title: Automated acoustic matrix deposition for MALDI sample preparation publication-title: Anal Chem doi: 10.1021/ac051534r – volume: 3 start-page: 636 year: 2004 ident: 10.1016/j.cbpa.2006.11.035_bib8 article-title: Protein expression profiling of endometrial malignancies reveals a new tumor marker: chaperonin 10 publication-title: J Proteome Res doi: 10.1021/pr049975z – volume: 14 start-page: 752 year: 2003 ident: 10.1016/j.cbpa.2006.11.035_bib17 article-title: Spatial profiling invertebrate ganglia using MALDI MS publication-title: J Am Soc Mass Spectrom doi: 10.1016/S1044-0305(03)00288-5 – volume: 41 start-page: 705 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib29_1 article-title: Optimizing UV laser focus profiles for improved MALDI performance publication-title: J Mass Spectrom doi: 10.1002/jms.1041 – volume: 126 start-page: 177 year: 2005 ident: 10.1016/j.cbpa.2006.11.035_bib21 article-title: MALDI mass spectrometric imaging of biological tissue sections publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2004.09.032 – volume: 7 start-page: 493 year: 2001 ident: 10.1016/j.cbpa.2006.11.035_bib6 article-title: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues publication-title: Nat Med doi: 10.1038/86573 – volume: 60 start-page: 2299 year: 1988 ident: 10.1016/j.cbpa.2006.11.035_bib2 article-title: Laser desorption ionization of proteins with molecular masses exceeding 10, 000 daltons publication-title: Anal Chem doi: 10.1021/ac00171a028 – volume: 10 start-page: 981 year: 2004 ident: 10.1016/j.cbpa.2006.11.035_bib9 article-title: Protein profiling in brain tumors using mass spectrometry: feasibility of a new technique for the analysis of protein expression publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-0927-3 – volume: 2 start-page: 151 year: 1988 ident: 10.1016/j.cbpa.2006.11.035_bib3 article-title: Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry publication-title: Rapid Commun Mass Spectrom doi: 10.1002/rcm.1290020802 – volume: 63 start-page: 1652 year: 2003 ident: 10.1016/j.cbpa.2006.11.035_bib7 article-title: Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin A as potential molecular targets in non-small cell lung cancer publication-title: Cancer Res – volume: 20 start-page: 965 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib23_1 article-title: Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue publication-title: Rapid Commun Mass Spectrom doi: 10.1002/rcm.2397 – volume: 16 start-page: 1093 year: 2005 ident: 10.1016/j.cbpa.2006.11.035_bib18_1 article-title: Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry publication-title: J Am Soc Mass Spectrom doi: 10.1016/j.jasms.2005.02.026 – volume: 76 start-page: 1145 year: 2004 ident: 10.1016/j.cbpa.2006.11.035_bib16 article-title: Integrating histology and imaging mass spectrometry publication-title: Anal Chem doi: 10.1021/ac0351264 – volume: 12 start-page: 5142 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib15 article-title: Selective profiling of proteins in lung cancer cells from fine-needle aspirates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-06-0264 – volume: 246 start-page: 64 year: 1989 ident: 10.1016/j.cbpa.2006.11.035_bib4 article-title: Electrospray ionization for mass spectrometry of large biomolecules publication-title: Science doi: 10.1126/science.2675315 – volume: 78 start-page: 53 year: 1987 ident: 10.1016/j.cbpa.2006.11.035_bib1 article-title: Matrix-assisted ultraviolet laser desorption of non-volatile compounds publication-title: Int J Mass Spectrom Ion Process doi: 10.1016/0168-1176(87)87041-6 – volume: 78 start-page: 6448 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib24_1 article-title: Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry publication-title: Anal. Chem. doi: 10.1021/ac060788p – volume: 38 start-page: 1081 year: 2003 ident: 10.1016/j.cbpa.2006.11.035_bib22 article-title: Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry publication-title: J Mass Spectrom doi: 10.1002/jms.525 – volume: 44 start-page: 7094 year: 2005 ident: 10.1016/j.cbpa.2006.11.035_bib27 article-title: Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization publication-title: Angew Chem Int Ed Engl doi: 10.1002/anie.200502362 – volume: 362 start-page: 433 year: 2003 ident: 10.1016/j.cbpa.2006.11.035_bib11 article-title: Proteomic patterns of tumour subsets in non-small-cell lung cancer publication-title: Lancet doi: 10.1016/S0140-6736(03)14068-8 – volume: 69 start-page: 4751 year: 1997 ident: 10.1016/j.cbpa.2006.11.035_bib5 article-title: Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS publication-title: Anal Chem doi: 10.1021/ac970888i – volume: 65 start-page: 7674 year: 2005 ident: 10.1016/j.cbpa.2006.11.035_bib10_1 article-title: Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-3016 – volume: 78 start-page: 809 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib28 article-title: Solid ionic matrixes for direct tissue analysis and MALDI imaging publication-title: Anal Chem doi: 10.1021/ac0514669 – volume: 5 start-page: 262 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib20 article-title: Decreased striatal levels of PEP-19 following MPTP lesion in the mouse publication-title: J Proteome Res doi: 10.1021/pr050281f – volume: 18 start-page: 3051 year: 2004 ident: 10.1016/j.cbpa.2006.11.035_bib25 article-title: Determination of pharmaceutical compounds in skin by imaging matrix-assisted laser desorption/ionisation mass spectrometry publication-title: Rapid Commun Mass Spectrom doi: 10.1002/rcm.1725 – volume: 81 start-page: 613 year: 2005 ident: 10.1016/j.cbpa.2006.11.035_bib19_1 article-title: Direct profiling of the cerebellum by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a methodological study in postnatal and adult mouse publication-title: J Neurosci Res doi: 10.1002/jnr.20590 – volume: 5 start-page: 1975 year: 2006 ident: 10.1016/j.cbpa.2006.11.035_bib14 article-title: A novel histology directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancer publication-title: Molecular and Cellular Proteomics doi: 10.1074/mcp.M600119-MCP200 – volume: 77 start-page: 6682 year: 2005 ident: 10.1016/j.cbpa.2006.11.035_bib26 article-title: Localization and analyses of small drug molecules in rat brain tissue sections publication-title: Anal Chem doi: 10.1021/ac050868d
SSID	ssj0006285
Score	2.3134239
SecondaryResourceType	review_article
Snippet	The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	29
SubjectTerms	Animals Biomarkers - analysis Cerebellum - chemistry Cerebellum - metabolism Cerebellum - pathology Humans Mice Neoplasms - chemistry Neoplasms - metabolism Neoplasms - pathology Neurosciences - methods Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Proteins - analysis Proteins - chemistry Proteins - metabolism Rats Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends Technology, Pharmaceutical - methods Tissue Distribution Tissue Extracts - analysis Tissue Extracts - chemistry Tissue Extracts - metabolism
Title	MALDI-MS-based imaging of small molecules and proteins in tissues
URI	https://dx.doi.org/10.1016/j.cbpa.2006.11.035 https://www.ncbi.nlm.nih.gov/pubmed/17185024 https://www.proquest.com/docview/19648128 https://www.proquest.com/docview/68992341
Volume	11
WOSCitedRecordID	wos000244807600005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-0402 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0006285 issn: 1367-5931 databaseCode: AIEXJ dateStart: 19970601 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9swEBdrOthextbuI_vo9DD2Ejwsf54eQ9axjrUM2kHejCVLkLLYIU5Hu79-J0ty0paUbbAXY4ScyPqdT3fS3e8IeSdDDkkkIZBhFQVJJERQpjoJmBK4HKs40yC7YhP5yQlMp_ybC8hsu3ICeV3D5SVf_FeosQ3BNqmzfwF3_6PYgPcIOl4Rdrz-EfDH468fj4Lj08AsUNVoNnd1iPSonZtz6LktiKtaxxHQmHqXXVTsqgOh3bRXPX2TSatyUZHSUww4_qb-yEZd_bL4-_DSUb-xPCkXS-w920jld9uwfsMh9zHKfhfMZ8Ksw46M4oxR4abcaXRl2yA3By_hdW3LbkmVU518YxG2FCa31LvdaTj_IMWitAdJhoHVdr5Bm31qRmQGFBqTjjPYIbsRNsCA7I6PDqdf-vXaJJHa7Dz7Bi61ykYB3vynbebLNvekM1POHpNHzr-gYysXT8g9Ve-R_XFdrpr5FX1Pu4jfDrc98mDiq_3tk_F1saFObGijaSc2tBcbimJDvdjQWU2d2Dwl3z8dnk0-B668RiCTlK0CprmKSg0VxCqPtajCkkUyiw1loEDHWuXKJErzFHgCMtYyTpMqQw8i44KHmYqfkUHd1OoFoUxArrFbmEqR6KgUwNJKqRIkWvh5BUPC_KwV0nHPmxIoPwofZHhemJk2RVEzdEoLnOkhGfXPLCzzyp29Uw9G4WxHaxMWKDt3PvfWI1fgjJvTsrJWzUVbGKY6tH5he48MOLpHCRuS5xby9TjR4kvR-n35j6N6RR6uv7zXZLBaXqg35L78iYguD8hOPoUDJ8a_AfhtsK4
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MALDI-MS-based+imaging+of+small+molecules+and+proteins+in+tissues&rft.jtitle=Current+opinion+in+chemical+biology&rft.au=Reyzer%2C+Michelle+L&rft.au=Caprioli%2C+Richard+M&rft.date=2007-02-01&rft.pub=Elsevier+Ltd&rft.issn=1367-5931&rft.eissn=1879-0402&rft.volume=11&rft.issue=1&rft.spage=29&rft.epage=35&rft_id=info:doi/10.1016%2Fj.cbpa.2006.11.035&rft.externalDocID=S1367593106001918
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1367-5931&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1367-5931&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1367-5931&client=summon