Algorithms for optimizing cross-overs in DNA shuffling

Background DNA shuffling generates combinatorial libraries of chimeric genes by stochastically recombining parent genes. The resulting libraries are subjected to large-scale genetic selection or screening to identify those chimeras with favorable properties (e.g., enhanced stability or enzymatic act...

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Bibliographic Details
Published in:	BMC bioinformatics Vol. 13; no. Suppl 3; p. S3
Main Authors:	He, Lu, Friedman, Alan M, Bailey-Kellogg, Chris
Format:	Journal Article
Language:	English
Published:	London BioMed Central 21.03.2012 Springer Nature B.V
Subjects:	African Swine Fever Virus - enzymology Algorithms Amino Acid Sequence Amino acid substitution Amino acids Animals Bacteria - enzymology beta-Lactamases - chemistry beta-Lactamases - genetics Bioinformatics Biology Biomedical and Life Sciences Chimeras Codon Codons Combinatorial libraries Computational Biology/Bioinformatics Computer Appl. in Life Sciences Computer applications Conferences Deoxyribonucleic acid DNA DNA Shuffling DNA-directed DNA polymerase E coli Engineers Enzymatic activity Escherichia coli - enzymology Free energy Gene Library Humans Integer programming Libraries Life Sciences Methods Microarrays Nearest-neighbor Nucleotide sequence Oligonucleotides Phosphoribosylglycinamide Formyltransferase - genetics Proceedings Protein Engineering - methods Rats Recombination Sequence Alignment Software Stochasticity Studies transformylase Diversity Variance African Swine Fever Virus Codon Free Energy Dynamic Programming Algorithm
ISSN:	1471-2105, 1471-2105
Online Access:	Get full text
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